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Fig. 4 | BMC Neurology

Fig. 4

From: Structural and functional implications of SLC13A3 and SLC9A6 mutations: an in silico approach to understanding intellectual disability

Fig. 4

Comparative Binding Site Representations of SLC9A6 and SLC13A3. (A) Ribbon depiction of the SLC9A6 ion-binding site in the 6-transmembrane (TM) core transport domain, superimposed on NHE9 (PDB ID: 6Z3Y). A detailed view of the predicted ion-binding site of SLC9A6, with crucial residues displayed as yellow sticks and labeled accordingly. Corresponding residues in the NHE9 structure are indicated in orange. (B) Ribbon depiction of the SLC13A3 sodium and substrate binding site, superimposed on SLC13A5 (PDB ID: 7JSK). A detailed view of the predicted binding site of SLC13A3 is shown, with crucial residues represented as yellow sticks and labeled. Corresponding residues in the SLC13A5 structure are shown in orange

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BMC Neurology

ISSN: 1471-2377

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