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  1. Research article

    Low threshold unmyelinated mechanoafferents can modulate pain

    Human, hairy skin contains a subgroup of C-fibers, the C-low threshold mechanoreceptive afferents ((C-LTMR) C-tactile or C-touch (CT) fibers) that are linked with the signaling of affective aspects of human to...

    Kathrin Habig, Anne Schänzer, Wolfgang Schirner, Gothje Lautenschläger, Benjamin Dassinger, Håkan Olausson, Frank Birklein, Elke R. Gizewski and Heidrun H. Krämer

    BMC Neurology 2017 17:184

    Published on: 15 September 2017

  2. Research article

    Anatomic mapping of molecular subtypes in diffuse glioma

    Tumor location served as an important prognostic factor in glioma patients was considered to postulate molecular features according to cell origin theory. However, anatomic distribution of unique molecular sub...

    Qisheng Tang, Yuxi Lian, Jinhua Yu, Yuanyuan Wang, Zhifeng Shi and Liang Chen

    BMC Neurology 2017 17:183

    Published on: 15 September 2017

  3. Case report

    A novel frameshift GRN mutation results in frontotemporal lobar degeneration with a distinct clinical phenotype in two siblings: case report and literature review

    Progranulin gene (GRN) mutations are major causes of frontotemporal lobar degeneration. To date, 68 pathogenic GRN mutations have been identified. However, very few of these mutations have been reported in Asians...

    Takashi Hosaka, Kazuhiro Ishii, Takeshi Miura, Naomi Mezaki, Kensaku Kasuga, Takeshi Ikeuchi and Akira Tamaoka

    BMC Neurology 2017 17:182

    Published on: 15 September 2017

  4. Study protocol

    Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients with hereditary ATTR amyloidosis with polyneuropathy

    Patisiran is an investigational RNA interference (RNAi) therapeutic in development for the treatment of hereditary ATTR (hATTR) amyloidosis, a progressive disease associated with significant disability, morbid...

    David Adams, Ole B. Suhr, Peter J. Dyck, William J. Litchy, Raina G. Leahy, Jihong Chen, Jared Gollob and Teresa Coelho

    BMC Neurology 2017 17:181

    Published on: 11 September 2017

  5. Study protocol

    Research on advanced intervention using novel bone marrOW stem cell (RAINBOW): a study protocol for a phase I, open-label, uncontrolled, dose-response trial of autologous bone marrow stromal cell transplantation in patients with acute ischemic stroke

    Stroke is a leading cause of death and disability, and despite intensive research, few treatment options exist. However, a recent breakthrough in cell therapy is expected to reverse the neurological sequelae o...

    Hideo Shichinohe, Masahito Kawabori, Hiroaki Iijima, Tuyoshi Teramoto, Takeo Abumiya, Naoki Nakayama, Ken Kazumata, Shunsuke Terasaka, Teruyo Arato and Kiyohiro Houkin

    BMC Neurology 2017 17:179

    Published on: 8 September 2017

  6. Research article

    Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model

    Alexander disease (AxD) is an astrogliopathy that predominantly affects the white matter of the central nervous system (CNS), and is caused by a mutation in the gene encoding the glial fibrillary acidic protei...

    So-Hyun Lee, Tai-Seung Nam, Kun-Hee Kim, Jin Hee Kim, Woong Yoon, Suk-Hee Heo, Min Jung Kim, Boo Ahn Shin, Ming-Der Perng, Hyon E. Choy, Jihoon Jo, Myeong-Kyu Kim and Seok-Yong Choi

    BMC Neurology 2017 17:175

    Published on: 7 September 2017

  7. Research article

    Caught in a no-win situation: discussions about CCSVI between persons with multiple sclerosis and their neurologists – a qualitative study

    In recent years, shared decision making (SDM) has been promoted as a model to guide interactions between persons with MS and their neurologists to reach mutually satisfying decisions about disease management –...

    S. Michelle Driedger, Ryan Maier, Ruth Ann Marrie and Melissa Brouwers

    BMC Neurology 2017 17:176

    Published on: 7 September 2017

  8. Research article

    Phenotypic expressions of hereditary Transthyretin Ala97Ser related Amyloidosis (ATTR) in Taiwanese

    The disease course and early signs specific to ATTR Ala97Ser, the most common endemic mutation in Taiwan, have not been well described. Since new medications can slow down the rate of disease progression, the ...

    Hui-Ching Hsu, Ming-Feng Liao, Jung-Lung Hsu, Ai-Lun Lo, Hung-Chou Kuo, Rong-Kuo Lyu, Victor Chien-Chia Wu, Chih-Wei Wang and Long-Sun Ro

    BMC Neurology 2017 17:178

    Published on: 7 September 2017

  9. Research article

    Amyotrophic lateral sclerosis modifies progenitor neural proliferation in adult classic neurogenic brain niches

    Adult neurogenesis persists through life at least in classic neurogenic niches. Neurogenesis has been previously described as reduced in neurodegenerative diseases. There is not much knowledge about is adult n...

    Lucía Galán, Ulises Gómez-Pinedo, Antonio Guerrero, Jose Manuel García-Verdugo and Jorge Matías-Guiu

    BMC Neurology 2017 17:173

    Published on: 6 September 2017

  10. Research article

    Adherence, satisfaction and functional health status among patients with multiple sclerosis using the BETACONNECT® autoinjector: a prospective observational cohort study

    Maintaining patient adherence to disease modifying drugs in multiple sclerosis is a challenge, which can be improved by autoinjectors. The BETACONNECT® is a fully electronic autoinjector for the injection of i...

    Ingo Kleiter, Michael Lang, Judith Jeske, Christiane Norenberg, Barbara Stollfuß and Markus Schürks

    BMC Neurology 2017 17:174

    Published on: 6 September 2017

  11. Research article

    Subjective patient-reported versus objective adherence to subcutaneous interferon β-1a in multiple sclerosis using RebiSmart®: the CORE study

    Patient adherence to treatment is key to preventing the worsening of neurological disability in multiple sclerosis (MS). The RebiSmart® autoinjector facilitates self-administration of subcutaneous interferon β...

    Chiara Zecca, Giulio Disanto, Sarah Mühl and Claudio Gobbi

    BMC Neurology 2017 17:171

    Published on: 4 September 2017

  12. Research article

    Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke

    While neurogranin has no value as plasma biomarker for Alzheimer’s disease, it may be a potential blood biomarker for traumatic brain injury. This evokes the question whether there are changes in neurogranin l...

    Ann De Vos, Maria Bjerke, Raf Brouns, Naomi De Roeck, Dirk Jacobs, Lien Van den Abbeele, Kaat Guldolf, Henrik Zetterberg, Kaj Blennow, Sebastiaan Engelborghs and Eugeen Vanmechelen

    BMC Neurology 2017 17:170

    Published on: 30 August 2017

  13. Research article

    Evoked potentials after painful cutaneous electrical stimulation depict pain relief during a conditioned pain modulation

    Conditioned pain modulation (CPM) evaluates the pain modulating effect of a noxious conditioning stimulus (CS) on another noxious test stimulus (TS), mostly based solely on subjective pain ratings. We used pai...

    Oliver Höffken, Özüm S. Özgül, Elena K. Enax-Krumova, Martin Tegenthoff and Christoph Maier

    BMC Neurology 2017 17:167

    Published on: 29 August 2017

  14. Research article

    Clinical features and the degree of cerebrovascular stenosis in different types and subtypes of cerebral watershed infarction

    Whether there are differences in pathogenesis among different types and subtypes of cerebral watershed infarction (WSI) is controversial since they have been combined into a single group in most previous studies.

    Yue Li, Man Li, Xiaoyu Zhang, Shuna Yang, Huimin Fan, Wei Qin, Lei Yang, Junliang Yuan and Wenli Hu

    BMC Neurology 2017 17:166

    Published on: 29 August 2017

  15. Research article

    Cilostazol improves endothelial function in acute cerebral ischemia patients: a double-blind placebo controlled trial with flow-mediated dilation technique

    In order to evaluate the impact of cilostazol on endothelial function, we compared the changes of flow-mediated dilation (FMD) between aspirin and cilostazol groups in patients with acute cerebral ischemia.

    Seong-Joon Lee, Jin Soo Lee, Mun Hee Choi, Sung Eun Lee, Dong Hoon Shin and Ji Man Hong

    BMC Neurology 2017 17:169

    Published on: 29 August 2017

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