Fig. 2

Analysis of the molecular profile of the WNT pathway in cortical tissue. A) Ilustration of methodology used to obtain the results of analysis of the expression profile of the genes of the WNT pathway using the super array technique in dysplastic and NAAC tissue. B) Comparison of ΔCT values of the genes analyzed by heat map of cortical tissue with dysplastic lesion, NAAC and control cortical for patient 1 (B) and patient 2 (D). These different tissues are showed in the columns and represented by labeled red (dysplastic tissue), green (NAAC) and without labeled (control) in the illustrative brain image. C and E) Analysis of percentage of ΔCT of patiens stratifying the genes analyzed by the difference in behavior in the comparison of the 3 different tissues analyzed, thus being able to identify which genes present similarity and/or difference between the tissue with dysplasia and the adjacent tissue compared to the control. The separation of this genes allows observe the different presentation relationship with the genes expression comparing the three tissues, being watched genes with ΔCT values similar in the dysplastic, NAAC and control, and genes with different expression sometimes with control, NAAC and dysplastic tissue for patient 1 (C) and patient 2 E). (≠ different / ≡ similar)