Corneal confocal microscopy in the evaluation of immune-related motor neuron disease syndrome

BMC Neurology

Table 1 Comparison of demographics and CCM parameters

	Control (n = 10)	ALS (n = 33)	Immune-related MND syndrome (n = 39)	P
Age	43.8 ± 20.5	48.6 ± 11.1	55 ± 8.8	0.019^*a
Sex (male:female)	4:6	24:9	18:21	0.076^b
Diagnostic delay (months)	-	26.29	27	0.321
Site of onset (bulbar/limb)	-	3:30	7:32	0.282
ALSFRS-R	-	39.7 ± 5.4	40.2 ± 6.3	0.321
KCSS	-	2 ± 0.9	1.9 ± 0.5	0.229
ΔFS	-	0.7 ± 0.7	0.4 ± 0.4	0.205
LC density (cells/mm²)^**	21.8(17.1)	45.8(54.1)	104.1(81.2)	< 0.01^*c
IWL (mm/mm²)	22.6 ± 4.6	16.4 ± 3.9	18.9 ± 4.7	0.001^*d

Data are expressed as means ± standard deviations unless otherwise indicated
ALSFRS-R amyotrophic lateral sclerosis functional rating score-revised, KCSS clinical severity scale, ΔFS disease progression rate
^* P < 0.05
^** LC density expressed as the median(interquartile)
^a ALS and immune-related MND syndrome vs. control; P = 0.019; ALS vs. immune-related MND syndrome; P = 0.013; control vs. ALS; P = 0.127
^b ALS and immune-related MND syndrome vs. control; P = 0.076
^c ALS and immune-related MND syndrome vs. control; P = 0.010; ALS vs. immune-related MND syndrome; P < 0.01; ALS vs control; P = 0.007
^d ALS and immune-related MND syndrome vs. control; P = 0.001; ALS vs. immune-related MND syndrome; P = 0.011; ALS vs control; P = 0.001

ISSN: 1471-2377