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Table 7 Comparisons of clinical characteristics among patients with different genotypes of selected SNPs

From: CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study

Characteristics

CYP3A4 rs3735451

CYP3A4 rs4646440

TT

TC

CC

p

AA

AG

GG

p

TP (g/L)

66.16 ± 6.02

64.65 ± 5.34

66.79 ± 6.09

0.021

66.98 ± 6.96

64.60 ± 5.33

66.02 ± 5.92

0.043

Serum uric acid (μmol/L)

290.64 ± 97.14

279.93 ± 93.17

260.83 ± 72.42

0.247

266.33 ± 61.31

280.39 ± 94.51

287.64 ± 95.95

0.583

Blood glucose (mmol/L)

6.36 ± 2.05

6.22 ± 2.33

6.77 ± 3.19

0.484

6.75 ± 2.92

6.35 ± 2.59

6.29 ± 2.02

0.734

TB (μmol/L)

13.78 ± 6.99

13.23 ± 5.32

14.95 ± 9.03

0.422

16.56 ± 11.62

13.36 ± 5.23

13.62 ± 6.75

0.237

TG (mmol/L)

1.55 ± 0.88

1.65 ± 1.24

1.53 ± 1.22

0.596

1.79 ± 1.43

1.60 ± 1.02

1.57 ± 1.06

0.771

Hemoglobin (g/L)

137.07 ± 21.57

137.51 ± 22.94

130.46 ± 31.22

0.395

133.57 ± 15.59

137.31 ± 25.98

136.82 ± 21.38

0.842

TC (mmol/L)

3.93 ± 0.99

3.89 ± 1.05

3.65 ± 1.19

0.464

3.92 ± 1.13

3.76 ± 1.10

3.96 ± 0.98

0.200

HDL-C (mmol/L)

1.10 ± 0.24

1.09 ± 0.26

1.03 ± 0.37

0.494

1.01 ± 0.31

1.07 ± 0.27

1.11 ± 0.25

0.203

LDL-C (mmol/L)

1.82 ± 0.56

1.82 ± 0.62

1.66 ± 0.56

0.446

1.80 ± 0.55

1.76 ± 0.65

1.84 ± 0.55

0.375

Characteristics

CYP11A1 rs12912592

CYP11A1 rs28681535

TT

GT

GG

p

TT

GT

GG

p

TP (g/L)

65.50 ± 0.56

65.32 ± 6.02

65.64 ± 5.78

0.910

65.72 ± 5.75

65.62 ± 5.82

65.46 ± 5.83

0.946

Serum uric acid (μmol/L)

245.50 ± 62.93

290.63 ± 99.32

284.76 ± 92.30

0.744

2810 ± 87.44

284.04 ± 93.26

290.48 ± 96.95

0.749

Blood glucose (mmol/L)

4.93 ± 0.21

6.57 ± 2.34

6.27 ± 2.23

0.397

6.85 ± 2.92

6.26 ± 2.12

6.11 ± 1.96

0.064

TB (μmol/L)

9.33 ± 2.82

12.02 ± 4.58

14.05 ± 6.84

0.025

13.71 ± 6.91

14.23 ± 7.35

12.75 ± 4.68

0.117

TG (mmol/L)

0.76 ± 0.39

1.65 ± 1.28

1.57 ± 0.99

0.342

1.33 ± 0.53

1.63 ± 1.05

1.63 ± 1.22

0.093

Hemoglobin (g/L)

130.67 ± 4.04

136.46 ± 27.08

136.94 ± 21.84

0.885

137.54 + 15.96

136.85 ± 24.84

136.31 ± 22.92

0.932

TC (mmol/L)

3.64 ± 0.33

3.97 ± 1.00

3.89 ± 1.02

0.774

3.96 ± 0.84

3.95 ± 1.10

3.81 ± 0.97

0.433

HDL-C (mmol/L)

1.21 ± 0.35

1.07 ± 0.24

1.09 ± 0.26

0.579

1.16 ± 0.27

1.08 ± 0.25

1.06 ± 0.24

0.027

LDL-C (mmol/L)

1.86 ± 0.20

1.84 ± 0.56

1.81 ± 0.59

0.871

1.88 ± 0.52

1.83 ± 0.62

1.75 ± 0.56

0.311

  1. SNP single nucleotide polymorphism, TP total protein, TB total bilirubin, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol
  2. p < 0.05 indicates statistical significance
  3. Bold indicates that the values have statistical significance