From: CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study
Characteristics | CYP3A4 rs3735451 | CYP3A4 rs4646440 | ||||||
TT | TC | CC | p | AA | AG | GG | p | |
TP (g/L) | 66.16 ± 6.02 | 64.65 ± 5.34 | 66.79 ± 6.09 | 0.021 | 66.98 ± 6.96 | 64.60 ± 5.33 | 66.02 ± 5.92 | 0.043 |
Serum uric acid (μmol/L) | 290.64 ± 97.14 | 279.93 ± 93.17 | 260.83 ± 72.42 | 0.247 | 266.33 ± 61.31 | 280.39 ± 94.51 | 287.64 ± 95.95 | 0.583 |
Blood glucose (mmol/L) | 6.36 ± 2.05 | 6.22 ± 2.33 | 6.77 ± 3.19 | 0.484 | 6.75 ± 2.92 | 6.35 ± 2.59 | 6.29 ± 2.02 | 0.734 |
TB (μmol/L) | 13.78 ± 6.99 | 13.23 ± 5.32 | 14.95 ± 9.03 | 0.422 | 16.56 ± 11.62 | 13.36 ± 5.23 | 13.62 ± 6.75 | 0.237 |
TG (mmol/L) | 1.55 ± 0.88 | 1.65 ± 1.24 | 1.53 ± 1.22 | 0.596 | 1.79 ± 1.43 | 1.60 ± 1.02 | 1.57 ± 1.06 | 0.771 |
Hemoglobin (g/L) | 137.07 ± 21.57 | 137.51 ± 22.94 | 130.46 ± 31.22 | 0.395 | 133.57 ± 15.59 | 137.31 ± 25.98 | 136.82 ± 21.38 | 0.842 |
TC (mmol/L) | 3.93 ± 0.99 | 3.89 ± 1.05 | 3.65 ± 1.19 | 0.464 | 3.92 ± 1.13 | 3.76 ± 1.10 | 3.96 ± 0.98 | 0.200 |
HDL-C (mmol/L) | 1.10 ± 0.24 | 1.09 ± 0.26 | 1.03 ± 0.37 | 0.494 | 1.01 ± 0.31 | 1.07 ± 0.27 | 1.11 ± 0.25 | 0.203 |
LDL-C (mmol/L) | 1.82 ± 0.56 | 1.82 ± 0.62 | 1.66 ± 0.56 | 0.446 | 1.80 ± 0.55 | 1.76 ± 0.65 | 1.84 ± 0.55 | 0.375 |
Characteristics | CYP11A1 rs12912592 | CYP11A1 rs28681535 | ||||||
TT | GT | GG | p | TT | GT | GG | p | |
TP (g/L) | 65.50 ± 0.56 | 65.32 ± 6.02 | 65.64 ± 5.78 | 0.910 | 65.72 ± 5.75 | 65.62 ± 5.82 | 65.46 ± 5.83 | 0.946 |
Serum uric acid (μmol/L) | 245.50 ± 62.93 | 290.63 ± 99.32 | 284.76 ± 92.30 | 0.744 | 2810 ± 87.44 | 284.04 ± 93.26 | 290.48 ± 96.95 | 0.749 |
Blood glucose (mmol/L) | 4.93 ± 0.21 | 6.57 ± 2.34 | 6.27 ± 2.23 | 0.397 | 6.85 ± 2.92 | 6.26 ± 2.12 | 6.11 ± 1.96 | 0.064 |
TB (μmol/L) | 9.33 ± 2.82 | 12.02 ± 4.58 | 14.05 ± 6.84 | 0.025 | 13.71 ± 6.91 | 14.23 ± 7.35 | 12.75 ± 4.68 | 0.117 |
TG (mmol/L) | 0.76 ± 0.39 | 1.65 ± 1.28 | 1.57 ± 0.99 | 0.342 | 1.33 ± 0.53 | 1.63 ± 1.05 | 1.63 ± 1.22 | 0.093 |
Hemoglobin (g/L) | 130.67 ± 4.04 | 136.46 ± 27.08 | 136.94 ± 21.84 | 0.885 | 137.54 + 15.96 | 136.85 ± 24.84 | 136.31 ± 22.92 | 0.932 |
TC (mmol/L) | 3.64 ± 0.33 | 3.97 ± 1.00 | 3.89 ± 1.02 | 0.774 | 3.96 ± 0.84 | 3.95 ± 1.10 | 3.81 ± 0.97 | 0.433 |
HDL-C (mmol/L) | 1.21 ± 0.35 | 1.07 ± 0.24 | 1.09 ± 0.26 | 0.579 | 1.16 ± 0.27 | 1.08 ± 0.25 | 1.06 ± 0.24 | 0.027 |
LDL-C (mmol/L) | 1.86 ± 0.20 | 1.84 ± 0.56 | 1.81 ± 0.59 | 0.871 | 1.88 ± 0.52 | 1.83 ± 0.62 | 1.75 ± 0.56 | 0.311 |