Table 3 Relationships between CYP3A4 and CYP11A1 polymorphism and ischemic stroke risk
From: CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study
Gene SNP ID | Model | Genotype | Case | Control | Adjusted by age and gender | |
|---|---|---|---|---|---|---|
OR (95%CI) | p | |||||
CYP3A4 rs3735451 | Allele | T | 705 | 686 | 1.00 | 0.039 |
C | 249 | 300 | 0.81 (0.66–0.98) | |||
Genotype | TT | 256 | 228 | 1.00 | ||
CT | 193 | 230 | 0.74 (0.57–0.97) | 0.029 | ||
CC | 28 | 35 | 0.66 (0.38–1.14) | 0.135 | ||
Dominant | TT | 256 | 228 | 1.00 | 0.018 | |
CT-CC | 221 | 265 | 0.73 (0.56–0.95) | |||
Recessive | TT-CT | 449 | 458 | 1.00 | 0.308 | |
CC | 28 | 35 | 0.76 (0.45–1.29) | |||
Log-additive | – | – | – | 0.78 (0.63–0.96) | 0.019 | |
CYP3A4 rs4646440 | Allele | G | 768 | 754 | 1.00 | 0.046 |
A | 186 | 228 | 0.80 (0.64–1.00) | |||
Genotype | GG | 307 | 282 | 1.00 | ||
GA | 154 | 190 | 0.72 (0.55–0.95) | 0.021 | ||
AA | 16 | 19 | 0.72 (0.36–1.45) | 0.362 | ||
Dominant | GG | 307 | 282 | 1.00 | 0.017 | |
GA-AA | 170 | 209 | 0.72 (0.55–0.94) | |||
Recessive | GG-GA | 461 | 472 | 1.00 | 0.560 | |
AA | 16 | 19 | 0.81 (0.41–1.62) | |||
Log-additive | – | – | – | 0.77 (0.61–0.97) | 0.024 | |