Table 4 Logistic regression models for prediction of early and late malignant progression with changes in MLS and ONSD/ETD ratio normalized by time interval

 Change from baseline in MLS, mm/hr. ^a

6.67 (1.51–29.53)

0.012

Change from baseline in ONSD/ETD, %/hr. ^a

1.64 (0.71–3.79)

0.249

 Age

1.08 (0.98–1.18)

0.114

Age

1.03 (0.97–1.09)

0.379

 Sex, male

0.77 (0.09–6.53)

0.814

Sex, male

0.77 (0.13–4.77)

0.783

 Initial DWI volume

1.02 (1.01–1.04)

0.006

Initial DWI volume

1.02 (1.01–1.03)

0.001

 Change from baseline in MLS, mm/day ^b

1.47 (1.08–2.01)

0.014

Change from baseline in ONSD/ETD, %/day ^b

1.38 (1.05–1.81)

0.021

 Age

0.93 (0.85–1.03)

0.178

Age

0.97 (0.9–1.04)

0.345

 Sex, male

0.24 (0.02–3.74)

0.308

Sex, male

0.78 (0.11–5.82)

0.811

 Initial DWI volume

1.02 (0.99–1.04)

0.136

Initial DWI volume

1.02 (1.00–1.04)

0.082