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Table 2 Inclusion and exclusion criteria

From: The effect of physical activity on cognition relative to APOE genotype (PAAD-2): study protocol for a phase II randomized control trial

Inclusion criteria

Instrumentation

Cutoff

40–65 years of age

Telephone interview

 

Family history of dementia

Telephone interview, Risk Evaluation and Education for Alzheimer’s disease (REVEAL) questionnaire

1 first degree relative or 2 second degree relatives diagnosed with dementia or AD [109]

Ability to communicate in English

Telephone interview

 

Not meeting PA guidelines

American College of Sports Medicine (ACSM)'s guidelines

30 min of moderate intensity PA fewer than 3x/week for the last 3 months [106]

Exclusion criteria

Instrumentation

Cutoff

Potential cognitive impairment

Modified Telephone Interview for Cognitive Status (TICS-m)

Total score < 33 [110]

Potential cognitive impairment

Montreal Cognitive Assessment (MoCA)

Total score < 26 [111]

Current use of medications to treat symptoms of AD or that adversely affect cognition

Self-report to a survey

 

Cannot attend PA because of cardiovascular, metabolic, or renal disease, or orthopedic limitations

Medical Health History (MHH), physician clearance

 

History of neurologic, psychiatric, or active functionally disabling disease, or any other conditions that might limit exercise or jeopardize participants

MHH questionnaire

 

Depression

Center for Epidemiological Studies Depression Scale - Revised (CESD-R)

Total score > 16 and having anhedonia or dysphoria nearly every day for the past 2 weeks, and 2 or more additional symptoms either nearly every day for the past 2 weeks or 5–7 days in the past week or indication for suicidal ideation [112]

Uncorrected hearing or visual impairments

Self-report to a survey

 

Plan for traveling for an extended period (more than 1 month) during the course of the study

Self-report to a survey

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