Table 4 Summary of findings – cryptococcal meningitis
Outcomes | Pooled outcome | № of participants (studies) | Quality of the evidence (GRADE) | Comments |
|---|---|---|---|---|
Survival | ||||
Survival follow up: 1 months | 17 (81.0%; range 62.5–100%) | ⨁◯◯◯ VERY LOW a,b,d,f,g,h,k | ||
Survival follow up: 6 months | 16 (76.2%; range 62.5–100%) | ⨁◯◯◯ VERY LOW a,b,d,f,g,h | ||
Survival follow up: 12 months | 20 (69.0%; range 33–100%) | ⨁◯◯◯ VERY LOW a,b,d,f,g,h,i | ||
AIDS specific mortality | ||||
AIDS specific mortality follow up: 1 months | 1 (4.8%; range 0–12.5%) | ⨁◯◯◯ VERY LOW a,b,d,f,g,h,k | ||
AIDS specific mortality follow up: 6 months | 3 (16.7%; range 12.5–33%) | ⨁◯◯◯ VERY LOW a,b,d,f,g,h,k | ||
AIDS specific mortality follow up: 12 months | 5 (29.4%; range 25–66%) | ⨁◯◯◯ VERY LOW a,b,d,f,g,h,k | ||
VPS survival | ||||
VPS survival follow up: 1 months | 8 (88.9%) | 9 (1 observational study) [72] | ⨁◯◯◯ VERY LOW a,d,e,f,g | Cherian, et al. [74] reported two shunt failures at unspecified timepoints. |
Corti, et al. [73] reported three shunt failures at unspecified timepoints. | ||||
VPS survival follow up: 6 months | 5 (83.3%) | 6 (1 observational study) [72] | ⨁◯◯◯ VERY LOW a,d,e,f,g | Cherian, et al. [74] reported two shunt failures at unspecified timepoints. |
Corti, et al. [73] reported three shunt failures at unspecified timepoints. | ||||
VPS survival follow up: 12 months | 5 (83.3%) | 6 (1 observational study) [72] | ⨁◯◯◯ VERY LOW a,d,e,f,g | Cherian, et al. [74] reported two shunt failures at unspecified timepoints and one at 12 months. |
Corti, et al. [73] reported three shunt failures at unspecified timepoints. | ||||
Operative complication | 4 (23.5%; range 0–50% | ⨁◯◯◯ VERY LOW a,b,c,d,e,f,g | Corti,et al. [73] reported one case of multiorgan failure or unspecified aetiology. | |
Validated outcome score | No studies reported validated outcome measures at any time point | Calvo, et al. [75] reported unvalidated outcome measures at 6 months | ||