Fig. 3

Correlation of serum α-synuclein with measures of the disease severity in epilepsy and acquired demyelinating disorders of CNS. (a-b) Correlation between the numbers of antiepileptic drug and serum levels of IL-1β (a) and IFN-γ (b). (a) Serum IL-1β levels showed a significant positive correlation with the numbers of antiepileptic drug taken for control of seizures in children with epilepsy (p = 0.0005, r = 0.3428). (b) Serum IFN-r levels showed a significant positive correlation with the numbers of antiepileptic drug for control of seizures in children with epilepsy (p = 0.0235, r = 0.2288)

(c-d) Correlation between the duration of last seizure before the blood collection and serum levels of α-synuclein (c) and IL-6 (d). (a) Serum α-synuclein levels showed a significant positive correlation with the duration of last seizure before the blood collection in children with epilepsy (p = 0.0438, r = 0.1884). (b) Serum IL-6 levels showed a significant positive correlation with the duration of last seizure before the blood collection in children with epilepsy (p = 0.0057, r = 0.2773). CNS, central nervous system; No, numbers; AED, numbers of anti-epileptic drug; IL, interleukin; IFN, interferon; sz, seizure.