Modern treatment of perineuriomas: a case-series and systematic review

Uerschels, Anne-Kathrin; Krogias, Christos; Junker, Andreas; Sure, Ulrich; Wrede, Karsten H.; Gembruch, Oliver

doi:10.1186/s12883-020-01637-z

BMC Neurology

Table 1 Results of the systematic review of the literature, including cases in which surgical treatment and follow-up is included

From: Modern treatment of perineuriomas: a case-series and systematic review

Year	Reference	Age (Years)	Sex	Nerve involved	Therapy	Follow-up	Outcome
1991	Phillips et al. [12]	Nm	male	ulnar	neurolysis complete resection + nerve graft	6 months	paralysis
1995	Emory et al. [5]	12	male	sciatic	fascicular biopsy	48 months	unchanged
		35	female	ulnar	fascicular biopsy	36 months	unchanged
		31	male	sciatic-tibial-branch	fascicular biopsy	17 months	unchanged
		15	male	median	fascicular biopsy	12 months	unchanged
		38	female	posterior interosseus	complete resection + nerve graft	3 months	worse
		18	female	femoral	complete resection + nerve graft	6 months	worse
		11	female	C8 & T1 nerve root	fascicular biopsy	1 months	unchanged
		13	female	peroneal	fascicular biopsy	3 months	unchanged
1998	Gruen et al. [13]	4	female	median	complete resection + nerve graft	5 years	improved
		14	female	peroneal	complete resection + nerve graft	2 years	little change
		8	male	peroneal	complete resection + nerve graft	2.5 years	foot brace
		4	male	median	complete resection + nerve graft	5 years	fair sensation, good thenar intrinsic motor function
		12	male	sciatic	internal neurolysis	4 years	Excellent pushdown, plantar sensation, foot brace
		38	female	median	internal neurolysis	6 years	reduced function
		21	female	brachial plexus	complete resection + nerve graft	6 years	unchanged
		16	female	peroneal	complete resection + nerve graft	4.25 years	improved
		37	male	ulnar	internal neurolysis	4 years	partial recovered
		37	male	radial	internal neurolysis	0,5 years	no follow-up
		16	male	median	complete resection + nerve graft	3 years	good recovery to date
		38	female	radial	complete resection + nerve graft	2 years	Good recovery to date
		8	female	peroneal	complete resection + nerve graft	0.5 years	none recovery
		43	female	peroneal	complete resection + nerve graft	1 year	early recovery
1999	Simmons et al. [14]	17	female	femoral	complete resection + nerve graft	10 months	unchanged
		12	female	sciatic	complete resection + nerve graft	2.5 years	unchanged
		26	female	brachial plexus	complete resection + nerve graft	2 months	unchanged
		19	male	Brachial plexus	neurolysis	6 months	improvement
2000	Jazayeri et al. [15]	53	male	Mmdian	complete resection + nerve graft	11 months	unchanged
2001	Alfonso et al. [16]	2	female	median	complete resection + nerve graft	12 months	unchanged
2001	Heilbrun et al. [17]	28	female	peroneal	dissection	5 years	unchanged
2004	Beekman et al. [18]	36	female	ulnar	neurolysis	6 months	improved
2004	Isaac et al. [19]	2	female	radial	Complete resection + nerve graft	3 years	unchanged
2005	Cortes et al. [20]	9	female	radial	complete resection + nerve graft	6 months	mild improvement
2007	Boyanton et al. [21]	5	male	ulnar	complete resection + nerve graft	3 years	some motor improvement
2007	Nguyen et al. [22]	30	female	radial	neurolysis, biopsy and tendon transfer	10 months	improved
2008	Gürkan et al. [23]	42	female	median	biopsy	16 months	improved
	Scheller et al. [24]	5	male	radial	complete resection + nerve graft	Postoperative Period	unchanged
		10	male	peroneal	complete resection + nerve graft	5 months	unchanged
		20	male	radial	complete resection + nerve graft	postoperative	first reinnervation
		29	male	ulnar	complete resection + nerve graft	postoperative	mild improvement
2009	Mauermann et al. [9]	12	female	sciatic	biopsy	5 months	unchanged
		7	malr	sciatic	biopsy	6 months	unchanged
		2	female	lumbosacral plexus	biopsy	18 months	Improvement in sensation
		12	female	sciatic	biopsy	78 months	unchanged
		35	male	tibial	biopsy	6 months	unchanged
		31	male	tibial	biopsy	177 months	improvement in stabbing sensation
		15	female	lumbosacral plexus	biopsy	88 months	mild increased weakness
		56	male	radial	biopsy	53 months	mild increased weakness
		19	female	femoral	biopsy	168 months	increased weakness
		7	female	sciatic	biopsy	118 months	unchanged
		34	male	sciatic	biopsy	45 months	increased numbness
		12	female	brachial plexus	biopsy	37 months	increased weakness
		35	male	brachial plexus	biopsy	36 months	worsened temperature discrimination
		30	female	radial	biopsy	27 months	improved in weakness and numbness
		14	male	sciatic	biopsy	24 months	increased atrophy
		30	male	sciatic	biopsy	18 months	unchanged
		12	male	brachial plexus	biopsy	34 months	increased atrophy
		8	male	sciatic	biopsy	135 months	improvement in weakness
		19	female	ulnar	biopsy	127 months	unchanged
		8	male	sciatic	biopsy	14 months	unchanged
		13	female	ulnar	biopsy	8 months	mild increased weakness
		37	male	tibial	biopsy	6 months	unchanged
	Sachanandani et al. [25]	23	female	median	fascicular biopsy	1 months	unchanged
2010	Ferraresi et al. [26]	4	male	peroneal	complete resection + nerve graft	7 years	unchanged
		9	male	sciatic	complete resection + nerve graft	8 years	unchanged
		13	female	peroneal	neurolysis	4 years	unchanged
		14	female	sciatic	neurolysis	5 years	unchanged
2011	Groeneweg [27]	22	male	ulnar	neurolysis + fascicular biopsy	nm	partial improvement
2012	Lavi et al. [28]	18	female	brachial plexus	biopsy + extzernal neurolysis	1 week	improved
2014	Chung et al. [29]	58	Female	brachial plexus	interfascicular dissection	18 months	nearly normal
2016	Dahlin et al. [30]	21	male	sciatic	fascicular biopsy	nm	unchanged
	McMillan et al. [31]	13	female	radial	complete resection + nerve graft	10 months	worse
	McMillan et al. [31]	14	female	femoral	complete resection + end-t-side nerve transfer	18 months	mild improvement
	Case 1	56	male	median	fascicular biopsy + neurolysis interfascicular	27 months	improvement
	Case 2	16	male	ulnar	fascicular biopsy + neurolysis interfascicular	24 months	improvement
	Case 3	17	female	peroneal	fascicular biopsy + neurolysis interfascicular	30 months	improvement

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