Table 2 Characteristics of the discontinued cases
No. | Sex | Onset | Dementia | Disease type | The reason of discontinuation of riluzole | Duration from the beginning of riluzole (days) | Duration of ALS at withdrawing riluzole (years) | Past histories |
|---|---|---|---|---|---|---|---|---|
Age, site | ||||||||
1 | M | 60, L | – | ALS | Nausea | 0–3 | 3 | BPH, Depressive status, HT |
2 | M | 77, C | – | ALS | IP | 60 | 1 | Past smoker, HT |
3 | F | 75, B | – | ALS | Progression of bulbar palsy | 3 | Diabetes | |
4 | F | 64, C | + | ALS/FTD | Appetite loss | 0–3 | 5 | |
5 | M | 77, C | + | ALS/FTD | Urinary urgency | 0–3 | 2 | OMI, Chronic gastritis |
6 | M | 53, C | – | ALS | Progression of bulbar palsy | 3 | ||
7 | M | 63, B | – | ALS | Refusal | 1 | Ventricular aneurism, HT | |
8 | M | 75, L | – | ALS | Dizziness | 90–120 | 20 | Emphysema, BA, HT, CAVB |
9 | F | 72, B | + | ALS/FTD | IP | 150 | 1 | HT, HL |
10 | F | 67, L | – | ALS | General malaise | 90 | 3 | none |
11 | F | 43, L | – | ALS | Chlamydia pneumonia s/o, IP n/r/o | 14 | 4 | none |
12 | M | 53, L | – | ALS | Paresthesia of tongue | 180 | 1 | Psoriasis vulgaris |
13 | M | 54, L | – | ALS | Elevated liver enzymes | 3 | 2 | Diabetes, HL |
14 | M | 56, B | – | ALS | Elevated liver enzymes / dizziness | 14 | 1 | Reflux esophagitis, Heavy drinker |
15 | F | 63, C | – | ALS | Dizziness | 4 | 2 | none |
16 | F | 67, C | – | ALS | Elevated liver enzymes / General malais | 30 | 5 | HL |
17 | F | 78, B | + | ALS/FTD | Appetite loss | 9 | 1 | HT, HL, Depressive status |
18 | M | 68, C | – | ALS | Elevated liver enzymes | 2–14 | 1 | Diabetes, HT |
19 | M | 65, C | – | ALS | Elevated liver enzymes / dizziness | 0–14 | 1 | Diabetes, HL |
20 | M | 59, C | – | ALS | IP | 60 | 2 | Past smoker, HT |