From: Case series of Creutzfeldt-Jakob disease in a third-level hospital in Quito
Diagnostic Certainty | Characteristic |
---|---|
Definite | Progressive neurological syndrome AND Neuropathologically or immunocytochemically or biochemically confirmed |
Probable | Rapidly progressive cognitive impairment |
Two or more of A – B – C – D | |
And | |
Typical EEG (Generalised periodic complexes) | |
OR | Rapidly progressive cognitive impairment |
Two or more of A – B – C – D | |
And | |
Typical MRI brain scan (High signal in caudate/putamen on MRI brain scan or at least two cortical regions temporal, parietal, occipital, either on DWI or FLAIR | |
OR | Rapidly progressive cognitive impairment |
Two or more of A – B – C – D | |
And | |
Positive 14–3-3 | |
OR | elaProgressive neurological syndrome and positive RT-QuIC in CSF or other tissues |
Possible | Rapidly progressive cognitive impairment |
two or more of A – B – C – D | |
And duration < 2 years |