Item | constipation pre-motor signs | constipation post-motor signs | Test value | P value |
---|---|---|---|---|
Number of case | N = 69 | N = 76 | / | / |
Male/Femaleb | 33/36 | 47/29 | χ2 = 2.873 | > 0.05 |
Age (year)a | 70.45 ± 8.41 | 68.66 ± 11.30 | t = 1.062 | 0.290 |
BMIa | 22.91 ± 3.17 | 22.49 ± 2.92 | t = 0.704 | 0.483 |
Moderate exerciseb | 15(21.74%) | 18(23.68%) | χ2 = 0.078 | > 0.05 |
Moderate drinkingb | 34(49.28%) | 46(60.53%) | χ2 = 1.851 | > 0.05 |
Smokingb | 7(10.14%) | 6(7.89%) | χ2 = 0.224 | > 0.05 |
Age of motor onset (year)a | 66.83 ± 9.28 | 61.20 ± 8.93 | t = 3.640 | 0.000 |
Age of diagnosis PD (year)a | 67.02 ± 8.94 | 62.88 ± 9.56 | t = 2.353 | 0.020 |
Motor onset to diagnosis (year)a | 1.01 ± 0.97 | 1.51 ± 1.71 | t = −1.955 | 0.053 |
Phenotype of onsetb | ||||
tremor-dominant | 43(62.32%) | 43(56.58%) | χ2 = 3.322 | > 0.05 |
Bradykinetic-rigid dominant | 22(31.88%) | 32(42.11%) | ||
others | 4(5.80%) | 1(1.32%) | ||
Duration of motor signs (year)a | 3.74 ± 3.96 | 8.50 ± 4.66 | t = −6.507 | 0.000 |
Duration of constipationa | 10.33 ± 10.13 | 4.48 ± 3.57 | t = 4.521 | 0.000 |
Dose of levodopa (mg/d)a | 467.89 ± 321.25 | 671.06 ± 338.72 | t = −3.488 | 0.001 |
LED (mg/d)a | 576.40 ± 368.61 | 807.22 ± 428.69 | t = −3.254 | 0.001 |
Daily levodopa/kg (mg/kg)a | 6.86 ± 6.05 | 11.15 ± 6.74 | t = −4.019 | 0.000 |
UPDRS scorea | 37.85 ± 24.96 | 49.55 ± 25.33 | t = −2.759 | 0.007 |
UPDRSIII scorea | 22.85 ± 14.72 | 28.58 ± 15.69 | t = −2.229 | 0.027 |
H-Yc | 2.02 ± 0.78 | 2.54 ± 0.87 | t = 3.714 | 0.000 |
NMSSa | 46.68 ± 39.06 | 58.85 ± 44.82 | t = −1.663 | 0.099 |
MMSEa | 26.68 ± 3.26 | 26.09 ± 4.37 | t = −0.858 | 0.393 |
PDSSa | 113.11 ± 26.27 | 110.08 ± 26.17 | t = −0.618 | 0.538 |
HAMAa | 12.10 ± 9.45 | 11.69 ± 9.47 | t = −0.243 | 0.809 |
HAMDa | 14.87 ± 11.57 | 15.84 ± 11.26 | t = 0.477 | 0.634 |
PDQ-39a | 31.79 ± 26.66 | 39.67 ± 29.34 | t = −1.593 | 0.114 |
Mild constipationb | 30(43.48%) | 48(63.16%) | χ2 = 6.161 | < 0.05 |
Severe constipationb | 38(55.07%) | 26(34.21%) | ||
CSSa | 14.35 ± 5.43 | 12.00 ± 5.66 | t = 2.490 | 0.014 |
PAC-QOLa | 71.80 ± 29.36 | 70.26 ± 25.20 | t = 0.287 | 0.775 |