Risk variants of the α-synuclein locus and REM sleep behavior disorder in Parkinson’s disease: a genetic association study

Table 2 Association results for pRBD with investigated SNCA and MAPT variants

dbSNP ID	Locus	Alleles	Frequency pRBD	Frequency Non-RBD	SE	OR	p value
Norwegian discovery dataset N = 141 pRBD-PD / 184 non-RBD-PD
rs356165	SNCA	G/A	0.42	0.42	0.163	1.07	0.76
rs3756063	SNCA	C/G	0.59	0.48	0.155	1.44	0.018
rs2245801	SNCA	T/C	0.11	0.14	0.261	0.79	0.36
rs2942168	MAPT	T/C	0.14	0.11	0.239	1.27	0.33
PPMI replication dataset: N = 106 pRBD-PD / 276 non-RBD-PD
rs3756063	SNCA	C/G	0.56	0.49	0.168	1.35	0.036^a
Meta-analysis across both datasets for rs3756063:					0.114	1.40	0.0032

The association between SNPs and RBD was tested in a logistic regression model, including age and gender as covariates. The first allele listed is the effect allele
Abbreviations: SNP single-nucleotide polymorphism, PD Parkinson’s disease, pRBD possible REM-sleep behavior disorder, OR odds ratio, SE standard error
^aOne-sided p-value

ISSN: 1471-2377