Table 2 Basic demographics and stroke characteristics for the total cohort as well as patients able (strictly personal) and unable to consent (legal representative)
From: Selection bias in clinical stroke trials depending on ability to consent
Total cohort | Strictly personal | Legal representative | P-value | OR (95% CI) | |
|---|---|---|---|---|---|
n (%) | 229 (100) | 120 (52.6) | 108 (47.4) | ||
Age, mean (SD) | 76.2 (11.3) | 73.9 (11.0) | 78.9 (11.3) | 0.001 | t-test |
Sex, % female | 55.5 | 50.0 | 61.1 | 0.110 | 1.6 (0.9–2.7) |
Pre-stroke mRS, median (IQR) | 0 (0–2) | 0 (0–1) | 1 (0–3) | 0.001 | MWU |
Pre-stroke living, n (%) | Somers‘Δ | 0.304 | |||
Independent at home | 171 (75.3) | 102 (86.4) | 68 (63.0) | ||
Requiring help, but at home | 34 (15.0) | 12 (10.2) | 22 (20.4) | ||
Nursing or retirement home | 22 (9.7) | 4 (3.4) | 18 (16.7) | ||
Admission NIHSS, median (IQR) | 14 (12–18) | 13 (11–15) | 17 (14–21) | < 0.001 | MWU |
Consciousness, n (%) | Somers’Δ | 0.340 | |||
Awake | 179 (78.2) | 107 (89.2) | 71 (65.7) | ||
Somnolent | 46 (20.1) | 13 (10.8) | 33 (30.6) | ||
Comatose | 4 (1.7) | 0 (0.0) | 4 (3.7) | ||
Thrombolysis, n (%) | 116 (50.7) | 65 (54.2) | 51 (47.2) | 0.353 | 0.8 (0.5–1.3) |
TOAST, n (%) | 0.044 | χ2 | |||
LAD | 58 (26) | 33 (28.2) | 24 (22.9) | ||
CAR | 112 (50.2) | 51 (43.5) | 61 (58.1) | ||
SVD | 6 (2.7) | 6 (5.1) | 0 (0.0) | ||
OTH | 4 (1.8) | 3 (2.6) | 1 (1.0) | ||
UNK | 43 (19.3) | 24 (20.5) | 19 (18.1) | ||
Dysphagia, n (%) | 164 (77) | 95 (81.9) | 69 (71.9) | 0.100 | 0.6 (0.3–1.1) |
Imaging proof of infarction, n (%) | 181 (96.3) | 91 (97.8) | 89 (94.7) | 0.444 | 0.4 (0.1–2.1) |
MCA infarction left | 97 (42.9) | 31 (26.3) | 66 (61.7) | < 0.001 | 4.5 (2.6–8.0) |
MCA infarction right | 121 (53.5) | 83 (70.3) | 37 (34.6) | < 0.001 | 0.2 (0.1–0.4) |
Brainstem lesion | 7 (3.1) | 7 (5.9) | 0 (0.0) | 0.015 | 0.9 (0.9–1.0) |
Other location | 15 (6.6) | 7 (5.9) | 8 (7.4) | 0.791 | 1.3 (0.4–3.6) |
Randomized to PCT-guidance | 112 (49.3) | 57 (47.9) | 55 (50.9) | 0.374 | 0.9 (0.5–1.5) |