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Table 1 Clinical and biochemical characteristics of survivor and non-survivor patients

From: Serum melatonin levels in survivor and non-survivor patients with traumatic brain injury

 

Non-survivors (n = 33)

Survivors (n = 85)

P value

Gender female – n (%)

13 (39.4)

15 (17.6)

0.02

Age (years) - median (p 25–75)

66 (55–75)

46 (28–62)

<0.001

Temperature (°C) - median (p 25–75)

36.0 (35.0–37.0)

37.0 (36.0–37.3)

0.12

Sodium (mEq/L)- median (p 25–75)

142 (138–148)

140 (138–143)

0.19

Glycemia (g/dL) - median (p 25–75)

160 (134–189)

139 (122–167)

0.08

Leukocytes-median*103/mm3 (p 25–75)

16.3 (9.8–22.7)

14.5 (10.3–19.0)

0.46

PaO2 (mmHg) - median (p 25–75)

133 (98–180)

148 (110–203)

0.34

PaO2/FI02 ratio - median (p 25–75)

274 (173–393)

336 (240–400)

0.11

Bilirubin (mg/dl) - median (p 25–75)

0.70 (0.58–0.95)

0.50 (0.40–0.80)

0.045

Creatinine (mg/dl) - median (p 25–75)

0.80 (0.70–1.10)

0.80 (0.63–1.00)

0.44

Hemoglobin (g/dL) - median (p 25–75)

11.9 (9.8–13.1)

11.4 (10.2–13.0)

0.87

GCS score - median (p 25–75)

3 (3–6)

7 (5–8)

<0.001

Lactic acid (mmol/L)-median (p 25–75)

2.40 (1.30–4.60)

1.70 (1.10–2.50)

0.06

Platelets - median*103/mm3 (p 25–75)

180 (125–237)

184 (134–244)

0.52

INR - median (p 25–75)

1.12 (1.03–1.40)

1.11 (1.00–1.21)

0.29

aPTT (seconds) - median (p 25–75)

29 (25–36)

28 (25–31)

0.31

Fibrinogen (mg/dl) - median (p 25–75)

361 (269–520)

366 (283–448)

0.99

APACHE-II score - median (p 25–75)

25 (23–28)

18 (14–22)

<0.001

ISS - median (ppe 25–75)

25 (25–25)

25 (25–29)

0.43

ICP (mmHg) - median (p 25–75)

25 (13–34)

15 (14–20)

0.28

CPP (mmHg) - median (p 25–75)

61 (54–69)

68 (57–70)

0.48

CT classification - n (%)

  

0.006

 Type 1

0

0

 

 Type 2

5 (15.2)

24 (28.2)

 

 Type 3

6 (18.2)

14 (16.5)

 

 Type 4

9 (27.3)

12 (14.1)

 

 Type 5

5 (15.2)

30 (35.3)

 

 Type 6

8 (24.2)

5 (5.9)

 

CT with high risk of death (types 3,4,6)- n (%)

23 (69.7)

31 (36.5)

0.002

Melatonin (pg/mL) - median (p 25–75)

6.74 (3.78–7.34)

2.49 (2.13–3.24)

<0.001

TAC (mmol/mL) - median (p 25–75)

5.09 (2.45–9.63)

2.36 (1.82–2.94)

<0.001

MDA (nmol/mL) - median (p 25–75)

2.01 (1.35–4.24)

1.36 (1.05–1.79)

<0.001

  1. P 25–75 percentile 25th - 75th, PaO 2 pressure of arterial oxygen/fraction inspired oxygen, FIO 2 pressure of arterial oxygen/fraction inspired oxygen, GCS Glasgow Coma Scale, ISS Injury Severity Score, INR international normalized ratio, aPTT activated partial thromboplastin time, APACHE II Acute Physiology and Chronic Health Evaluation, ICP intracranial pressure, CPP cerebral perfusion pressure, CT computer tomography, TAC total antioxidant capacity, MDA Malondialdehyde
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BMC Neurology

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