Fig. 3
From: Thrombocytopenia induced by dabigatran: two case reports
![Fig. 3](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12883-017-0900-8/MediaObjects/12883_2017_900_Fig3_HTML.gif)
Active sites of (a) Dabigatran-thrombin (PDB accession: 4YHI) and (b) Apixaban-factor Xa (PDB accession: 2P16). These inhibitors generate specific interactions to their target enzymes to prevent anti-coagulation. The hydrophobic and hydrophobic pharmacophores interact to their target enzymes. Blue, red, and gray represent the nitrogen, oxygen, and carbon atoms