Fig. 8From: Sex differences underlying orofacial varicella zoster associated pain in ratsVZV induced and aversive response that was affected by the estrous cycle. Weekly PEAP testing was completed on cycling female rats after VZV injection. A total of 24 rats whose whisker pad was injected with MeWo cells and a total of 25 rats whose whisker pad was injected with MeWo cells infected with 650 pfu/ μl VZV were included in this experiment. Smears were completed on each day of testing and the number of animals at each cycle phase (i.e., diestrus or proestrus/estrus) was a minimum of 8 rats but that number would vary from week to week depending on the estrous cycle. Testing was performed once a week for four weeks after whisker pad injection, in panel a testing was completed 1 week after injection, in panel b 2 weeks after injection, in panel c 3 weeks after injection and in panel d 4 weeks after injection. An asterisk indicates a significant difference (p < 0.05) between the Diestrus pOka group and the Proestrus/estrus pOka groupBack to article page