Fig. 7
From: Sex differences underlying orofacial varicella zoster associated pain in rats
OVX female rats show an increased VZV induced aversive response as compared to males. The whisker pads of male and intact or ovariectomized (OVX) female rats were injected with either MeWo cells or MeWo cells infected with 650 pfu/μl VZV (Sprague Dawley rats, panels a and b) or 360 pfu/μl VZV (Long Evans rats, panels c and d). PEAP testing was completed weekly over two weeks. The lower row of asterisks indicate a significant difference between the Female MeWo and Female pOka treatment groups (both intact and OVX) and the upper row of asterisks indicate a significant difference between the Male MeWo and Male pOka treatment groups. In panels b and d the bar with an asterisk indicates a significant difference (p < 0.05) between the Male pOka and the intact and OVX Female pOka treatment groups. In panel c the bar with an asterisk indicates a significant difference (p < 0.05) between the Male pOka and the intact Female POka treatment groups. The number of animals in each treatment group was pre-determined and is shown on the figure in parentheses