Neurocognitive function in HIV-infected persons with asymptomatic cryptococcal antigenemia: a comparison of three prospective cohorts

Table 1 Background and clinical characteristics of three study populations

	Cohort A			Cohort B			Cohort C
	Cryptococcal meningitis (N = 90)			Asymptomatic CRAG+ (N = 87)			HIV+ controls (N = 125)
	N	% or Median	(IQR)	N	% or Median	(IQR)	N	% or Median	(IQR)	A vs B P-value	B vs C P-value
Age (years)	90	36	(30–40)	87	31	(27–39)	125	37	(32–41)	0.02	<0.001
Sex	90			87			125
Male		60%			51%			32%
Female		40%			49%			68%		0.21	0.007
Education level (years)	90	8	(4–11)	87	7	(3–11)	125	8	(6–11)	0.15	0.05
< 7 years		36%			45%			27%
7 to 12 years		51%			44%			62%
> 12 years		13%			11%			10%		0.45	0.02
CD4 count (cells/uL)	79	17	(7–79)	86	26	(9–59)	125	233	(183–297)	0.93	<0.001
Karnofsky score	90	60	(50–70)	87	70	(60–80)	125	90	(90–90)	<0.001	<0.001
40		1%			0%			0%
50		28%			11%			0%
60		36%			20%			1%
70		29%			26%			0%
80		3%			29%			2%
90		3%			14%			97%
International HIV dementia scale	88			87			125
< =10		92%			75%			66%
> 10		8%			25%			34%		0.002	0.20
CES depression scale	88	23	(16–30)	87	18	(10–26)	125	9	(5–17)	0.007	<0.001
< 16		25%			41%			70%
> =16		75%			59%			30%		0.02	<0.001

Twenty participants from the cryptococcal meningitis cohort and 28 asymptomatic CrAg + participants were excluded due to insufficient data to calculate a QNPZ-8 score. P-values were calculated from student’s T-test (comparing means), Mann-Whitney U test, and chi-square test as appropriate

ISSN: 1471-2377