Fig. 4
From: Hyperekplexia, microcephaly and simplified gyral pattern caused by novel ASNS mutations, case report
MRI brain at the age of 3 weeks. a Sagittal T1-weighted image showing severe microcephaly with overlapped lambdoid sutures, brain underdevelopment evident by simplified gyral pattern, small cerebellum, and small pons. b Axial FLAIR image revealing small pons and cerebellum. c Axial T1-weighted image demonstrating delayed myelination evident by absent myelination of the posterior limb of internal capsule, bilaterally. d Coronal T2-weighted image showing simplified gyral pattern (more in the frontal lobes) and large extra-axial CSF spaces due to brain underdevelopment