Fig. 1

a. Phosphatidyl ethanolamine 16:0/28:0 levels in Multiple Sclerosis. Cross sectional serum samples from each of the clinical groups were subjected to lipidomic analysis utilizing tandem mass spectrometry. Bars represent mean value of the ratio of phosphatidyl ethanolamine 16:0/28:0 to the internal standard. Error bars represent ± SEM. RRMS <13 Y: Relapsing Remitting Multiple Sclerosis having less than 13 years of disease duration; RRMS > = 13 Y: Relapsing Remitting Multiple Sclerosis with >= 13 years of disease duration; SPMS: Secondary Progressive Multiple Sclerosis; PPMS: Primary Progressive Multiple Sclerosis. Letters shared in common indicate no significant difference between the respective groups ( p < 0.05, ANOVA followed by post hoc Sidak test of log normalized internal standard corrected analyte values). b. Ratio of Phosphatidyl ethanolamine 16:0/22:6 to phosphatidyl ethanolamine 16:0/18:3 in Multiple Sclerosis. Cross sectional serum samples from each of the clinical groups were subjected to lipidomic analysis utilizing tandem mass spectrometry. Bars represent mean value of phosphatidyl ethanolamine 16:0/22:6 normalized to phosphatidyl ethanolamine 16:0/18:3. Error bars represent ± SEM. RRMS <13 Y: Relapsing Remitting Multiple Sclerosis having less than 13 years of disease duration; RRMS > = 13 Y: Relapsing Remitting Multiple Sclerosis with >= 13 years of disease duration; SPMS: Secondary Progressive Multiple Sclerosis; PPMS: Primary Progressive Multiple Sclerosis. * p  < 0.05 vs controls (Student’s test). c. Plasmalogen ethanolamine 16:0/22:6 levels in Multiple Sclerosis. Cross sectional serum samples from each of the clinical groups were subjected to lipidomic analysis utilizing tandem mass spectrometry. Bars represent mean value of the ratio of plasmalogen ethanolamine 16:0/22:6 to the internal standard. Error bars represent ± SEM. RRMS <13 Y: Relapsing Remitting Multiple Sclerosis having less than 13 years of disease duration; RRMS > = 13 Y: Relapsing Remitting Multiple Sclerosis with >= 13 years of disease duration; SPMS: Secondary Progressive Multiple Sclerosis; PPMS: Primary Progressive Multiple Sclerosis. Letters shared in common indicate no significant difference between the respective groups ( p < 0.05, ANOVA followed by post hoc Sidak test of log normalized internal standard corrected analyte values). d. Ratio of Plasmalogen ethanolamine 16:0/22:6 to phosphatidyl ethanolamine 16:0/18:3 in Multiple Sclerosis. Cross sectional serum samples from each of the clinical groups were subjected to lipidomic analysis utilizing tandem mass spectrometry. Bars represent mean value of plasmalogen ethanolamine 16:0/22:6 normalized to phosphatidyl ethanolamine 16:0/18:3. Error bars represent ± SEM. RRMS <13 Y: Relapsing Remitting Multiple Sclerosis having less than 13 years of disease duration; RRMS > = 13 Y: Relapsing Remitting Multiple Sclerosis with >= 13 years of disease duration; SPMS: Secondary Progressive Multiple Sclerosis; PPMS: Primary Progressive Multiple Sclerosis. # p = 0.09 vs controls (Student’s test)