| Follow-up weeks | BITT |  | BoNT-A |  | BoNT-A additional effect |  | |||
---|---|---|---|---|---|---|---|---|---|---|
Yes (BoNT-A + BITT and BITT-only) | No (BoNT-A-only and control) | p-value | Yes (BoNT-A + BITT and BoNT-A-only) | No (BITT-only and control) | p-value | BoNT-A + BITT | BITT-only | p-value | ||
 | n = 16 | n = 5 |  | n = 12 | n = 9 |  | n = 9 | n = 7 |  | |
OSAS percentage of use both hands | 0 | 77.3 (2.4) | 81.0 (4.3) | Â | 78.2 (3.0) | 80.1 (3.5) | Â | 76.2 (3.3) | 78.5 (3.7) | Â |
6 | 77.7 (2.4) | 74.4 (4.7) | 0.193 | 80.3 (3.1) | 71.9 (3.8) | 0.019 | 82.8 (3.3) | 72.3 (3.7) | 0.011 | |
12 | 77.3 (2.4) | 77.4 (4.3) | 0.472 | 78.5 (3.0) | 76.2 (3.5) | 0.324 | 77.9 (3.3) | 76.8 (3.7) | 0.484 | |
18 | 76.8 (2.4) | 79.3 (4.7) | 0.822 | 78.7 (3.1) | 77.5 (3.8) | 0.469 | 78.2 (3.3) | 75.2 (3.7) | 0.275 | |
Making a sandwich p -value | ||||||||||
24 | 75.8 (2.4) | 76.7 (4.7) | 0.602 | 79.6 (3.1) | 72.8 (3.8) | 0.050 | 79.3 (3.3) | 72.2 (3.7) | 0.057 | |
overall | Â | Â | 0.737 | Â | Â | 0.127 | Â | Â | 0.087 | |
OSAS Quality grasp wrist | 0 | 1.62 (0.19) | 1.66 (0.34) | Â | 1.59 (0.24) | 1.70 (0.27) | Â | 1.65 (0.25) | 1.56 (0.28) | Â |
Making a sandwich (1–5) SDD 0.55 p -value | ||||||||||
6 | 1.71 (0.19) | 1.83 (0.35) | 0.732 | 1.79 (0.24) | 1.75 (0.28) | 0.434 | 1.82 (0.25) | 1.56 (0.28) | 0.471 | |
12 | 1.51 (0.19) | 1.79 (0.34) | 0.315 | 1.67 (0.24) | 1.62 (0.27) | 0.399 | 1.57 (0.25) | 1.43 (0.28) | 0.841 | |
18 | 1.66 (0.19) | 1.91 (0.35) | 0.423 | 1.76 (0.24) | 1.81 (0.28) | 0.756 | 1.70 (0.25) | 1.61 (0.28) | 0.983 | |
24 | 1.64 (0.19) | 1.75 (0.35) | 0.823 | 1.75 (0.24) | 1.64 (0.28) | 0.279 | 1.81 (0.250 | 1.45 (0.28) | 0.265 | |
overall | Â | Â | 0.846 | Â | Â | 0.814 | Â | Â | 0.746 | |
OSAS Quality grasp wrist | 0 | 1.71 (0.22) | 1.77 (0.39) | Â | 1.82 (0.28) | 1.66 (0.32) | Â | 1.93 (0.29) | 1.45 (0.33) | Â |
6 | 2.02 (0.22) | 2.35 (0.41) | 0.435 | 2.50 (0.28) | 1.87 (0.33) | 0.081 | 2.38 (0.29) | 1.65 (0.33) | 0.362 | |
Construction small (1–5) SDD 0.47 p -value | ||||||||||
12 | 2.00 (0.22) | 1.64 (0.39) | 0.163 | 2.14 (0.28) | 1.49 (0.32) | 0.064 | 2.31 (0.29) | 1.69 (0.33) | 0.615 | |
18 | 1.88 (0.22) | 1.89 (0.41) | 0.872 | 2.05 (0.28) | 1.73 (0.33) | 0.554 | 2.07 (0.29) | 1.69 (0.33) | 0.719 | |
24 | 1.76 (0.22) | 1.42 (0.41) | 0.226 | 1.70 (0.28) | 1.48 (0.33) | 0.830 | 2.00 (0.30) | 1.50 (0.33) | 0.926 | |
overall | Â | Â | 0.192 | Â | Â | 0.207 | Â | Â | 0.747 | |
OSAS Quality grasp wrist | 0 | 1.47 (0.17) | 1.53 (0.31) | Â | 1.47 (0.22) | 1.53 (0.25) | Â | 1.52 (0.24) | 1.41 (0.27) | Â |
6 | 1.64 (0.18) | 2.09 (0.32) | 0.130 | 2.12 (0.22) | 1.61 (0.26) | 0.010 | 1.90 (0.24) | 1.38 (0.27) | 0.107 | |
Construction large (1–5) SDD 0.81 p -value | ||||||||||
12 | 1.68 (0.17) | 1.78 (0.31) | 0.861 | 1.91 (0.22) | 1.56 (0.250 | 0.086 | 1.90 (0.24) | 1.45 (0.27) | 0.242 | |
18 | 1.72 (0.17) | 1.48 (0.33) | 0.455 | 1.63 (0.22) | 1.58 (0.26) | 0.716 | 1.77 (0.24) | 1.65 (0.27) | 0.957 | |
24 | 1.50 (0.17) | 1.11 (0.33) | 0.352 | 1.46 (0.22) | 1.15 (0.26) | 0.341 | 1.73 (0.24) | 1.24 (0.270 | 0.442 | |
overall | Â | Â | 0.084 | Â | Â | 0.026 | Â | Â | 0.169 | |
OSAS Quality hold wrist | 0 | 1.74 (0.19) | 1.76 (0.34) | Â | 1.65 (0.24) | 1.85 (0.27) | Â | 1.73 (0.25) | 1.72 (0.28) | Â |
6 | 1.98 (0.19) | 2.05 (0.36) | 0.881 | 2.17 (0.24) | 1.86 (0.29) | 0.053 | 2.27 (0.25) | 1.64 (0.28) | 0.044 | |
Making a sandwich (1–5) SDD 0.85 p -value | ||||||||||
12 | 1.62 (0.19) | 1.90 (0.34) | 0.420 | 1.77 (0.24) | 1.75 (0.27) | 0.434 | 1.72 (0.25) | 1.49 (0.28) | 0.506 | |
18 | 1.71 (0.19) | 2.09 (0.36) | 0.237 | 1.80 (0.24) | 2.01 (0.29) | 0.964 | 1.70 (0.25) | 1.69 (0.28) | 0.992 | |
24 | 1.76 (0.19) | 1.82 (0.35) | 0.899 | 1.70 (0.24) | 1.88 (0.28) | 0.937 | 1.82 (0.25) | 1.66 (0.28) | 0.380 | |
overall | Â | Â | 0.794 | Â | Â | 0.307 | Â | Â | 0.293 | |
OSAS Quality hold wrist | 0 | 1.86 (0.22) | 1.97 (0.40) | Â | 1.88 (0.28) | 1.95 (0.32) | Â | 1.93 (0.30) | 1.76 ((0.34) | Â |
6 | 2.08 (0.22) | 2.37 (0.42) | 0.628 | 2.54 (0.28) | 1.90 (0.34) | 0.021 | 2.44 (0.30) | 1.71 (0.34) | 0.078 | |
Construction small (1.5) SDD 0.81 p -value | ||||||||||
12 | 1.96 (0.22) | 1.81 (0.40) | 0.461 | 2.28 (0.28) | 1.50 (0.32) | 0.005 | 2.34 (0.30) | 1.58 (0.34) | 0.065 | |
18 | 1.98 (0.22) | 1.69 (0.42) | 0.293 | 2.17 (0.28) | 1.50 (0.34) | 0.017 | 2.27 (0.30) | 1.69 (0.34) | 0.199 | |
24 | 1.84 (0.22) | 1.74 (0.42) | 0.576 | 1.97 (0.28) | 1.61 (0.34) | 0.166 | 2.12 (0.30) | 1.54 (0.34) | 0.202 | |
overall | Â | Â | 0.576 | Â | Â | 0.037 | Â | Â | 0.351 | |
OSAS Quality hold wrist | 0 | 1.59 (0.18) | 1.52 (0.32) | Â | 1.67 (0.22) | 1.44 (0.26) | Â | 1.69 (0.26) | 1.49 (0.29) | Â |
6 | 1.74 (0.18) | 1.80 (0.34) | 0.678 | 2.00 (0.23) | 1.54 (0.28) | 0.400 | 1.97 (0.26) | 1.50 (0.30) | 0.367 | |
Construction large (1–5) SDD 0.58 p -value | ||||||||||
12 | 1.62 (0.18) | 1.67 (0.32) | 0.699 | 1.92 (0.22) | 1.36 (0.26) | 0.202 | 1.86 (0.26) | 1.39 (0.29) | 0.368 | |
18 | 1.89 (0.18) | 1.30 (0.34) | 0.104 | 1.77 (0.23) | 1.42 (0.27) | 0.663 | 2.04 (0.26) | 1.74 (0.29) | 0.729 | |
24 | 1.49 (0.18) | 1.36 (0.34) | 0.845 | 1.52 (0.23) | 1.32 (0.27) | 0.892 | 1.65 (0.26) | 1.31 (0.29) | 0.646 | |
overall | Â | Â | 0.260 | Â | Â | 0.603 | Â | Â | 0.874 |