Fig. 3
From: Comprehensive diagnostics in a case of hereditary diffuse leukodystrophy with spheroids
Light microscopy. Histological (a, b) and immunohistochemical (c-h) stainings. Biopsy specimens showing many reactive astrocytes (asterisks, a, b) on a loosened fibrillary CNS matrix. No proliferative activity is observed (c). Reactive astrocytes are strongly GFAP-positive (asterisk, d). MBP-positive myelin sheats are largely preserved (e). Numerous CD68-positive macrophages (arrow head, f) infiltrating CNS tissue were observed. NF-positive swollen axons (g) as well as NF- and APP-positive axonal spheroids (circle, g, h). (scale bares = 100 μm)