Table 5 Case–control analysis determining the association of pacemaker status with medication exposure

Had a code for dementia

10488 (10.9)

87460 (22.8)

0.42 (0.41, 0.42)

0.41 (0.41, 0.42)

0.41 (0.4, 0.42)

Cholinesterase inhibitor

1530 (1.6)

15055 (3.9)

0.40 (0.38, 0.42)

0.76 (0.76, 0.80)

0.75 (0.71, 0.79)

Ace-inhibitor/Angiotensin receptor blocker

19536 (20.4)

70672 (18.4)

1.13 (1.11, 1.15)

0.99 (0.98, 1.00)

1.03 (1.01, 1.04)

Insulin/oral hypoglycemic agent

6416 (6.7)

28900 (7.5)

0.88 (0.86, 0.91)

0.81 (0.81, 0.84)

0.83 (0.81, 0.86)

Proton pump inhibitors/H2-receptor blocker

8054 (8.4)

55903 (14.6)

0.54 (0.52, 0.55)

0.51 (0.51, 0.52)

0.53 (0.52, 0.55)

Selective serotonin reuptake inhibitor

2591 (2.7)

25525 (6.6)

0.39 (0.37, 0.41)

0.44 (0.44, 0.46)

0.45 (0.43, 0.47)

Statin

12746 (13.3)

53896 (14)

0.94 (0.92, 0.96)

0.84 (0.83, 0.85)

0.89 (0.87, 0.91)

Thiazide diuretic

4138 (4.3)

24407 (6.4)

0.66 (0.64, 0.69)

0.61 (0.61, 0.63)

0.64 (0.62, 0.66)

Thyroxine

4353 (4.5)

18660 (4.9)

0.93 (0.90, 0.96)

0.88 (0.88, 0.91)

0.9 (0.87, 0.94)

Vaughan-Williams drug class

Ia

272 (0.3)

352 (0.1)

3.10 (2.64, 3.63)

2.33 (2.29, 2.75)

2.38 (2, 2.82)

Ib

41 (0)

74 (0)

2.22 (1.51, 3.25)

1.47 (1.41, 2.20)

1.5 (0.99, 2.28)

Ic

907 (0.9)

840 (0.2)

4.35 (3.96, 4.78)

3.58 (3.54, 3.95)

3.66 (3.31, 4.05)

II (beta-blockers)

15770 (16.4)

38904 (10.1)

1.74 (1.71, 1.78)

1.60 (1.60, 1.63)

1.59 (1.56, 1.63)

III

3614 (3.8)

3939 (1)

3.77 (3.61, 3.95)

3.48 (3.46, 3.65)

3.47 (3.31, 3.65)

IV (calcium channel blockers)

6291 (6.6)

15501 (4)

1.67 (1.62, 1.72)

1.49 (1.49, 1.54)

1.48 (1.43, 1.53)

V (digoxin)

7965 (8.3)

17815 (4.6)

1.86 (1.81, 1.91)

1.69 (1.69, 1.74)

1.67 (1.62, 1.72)