Table 3 Frequency, severity and impact of headache according to migraineurs’ anxiety and depression status
|  | Migraine subjects without anxiety or depression, N = 93 Median (25% -75%) | Migraine subjects with anxiety alone, N = 28 median (25% -75%) | Migraine subjects with depression alone, N = 9 median (25% -75%) | Migraine subjects with anxiety and depression, N = 17 median (25% -75%) | P-value* | Post hoc analysis with Bonferroni’s correction |
|---|---|---|---|---|---|---|
Frequency per month | 1.0 (0.3-3.0) | 2.0 (1.0-5.0) | 1.0 (0.3-4.0) | 8.0 (2.5-21.0) | <0.001 | 1 vs. 2 = 0.596 |
1 vs.3 = 1.000 | ||||||
1 vs. 4 < 0.001 | ||||||
2 vs.3 = 1.000 | ||||||
2 vs. 4 = 0.003 | ||||||
3 vs. 4 = 0.001 | ||||||
VAS score for pain intensity | 6.0 (5.0-7.0) | 7.0 (6.0-8.0) | 7.0 (6.0-8.0) | 7.0 (5.0-9.0) | <0.001 | 1 vs. 2 = 0.011 |
1 vs.3 = 0.824 | ||||||
1 vs. 4 = 0.018 | ||||||
2 vs.3 = 1.000 | ||||||
2 vs. 4 = 1.000 | ||||||
3 vs. 4 = 1.000 | ||||||
HIT-6 score | 50.0 (46.0-58.0) | 57.0 (49.0-60.8) | 62.0 (52.0-70.5) | 64.0 (61.0-67.0) | <0.001 | 1 vs. 2 = 0.074 |
1 vs.3 = 0.004 | ||||||
1 vs. 4 < 0.001 | ||||||
2 vs.3 = 0.545 | ||||||
2 vs. 4 = 0.005 | ||||||
3 vs. 4 = 1.000 |