Drug | Food–drug interaction | Recommendation |
---|---|---|
Baclofen | No effect [37]. | Â |
Dantrolene | No effect [38]. | Â |
Pregabalin | Consuming with food decreased Cmaxby 25–30% and delayedtmaxby ≈3h [39]. |  |
Tizanidine | Simultaneous food intake with a tizanidinecapsule reduced Cmaxand AUCo–t by <20% and extendedtmax from 0.75 h to 1.5 h. | Extent of absorption is increased ≤20% relative to administration of the tizanidine capsule under fasted conditions. |
In contrast,simultaneous food consumption with a tizanidinetablet increased Cmax and AUCo–t by22.6% and 45.2%, respectively [40]. | The dosage forms of the tablet and capsule were not bioequivalent if administered with food. | |
Food increasedthe tmax and the extent of absorption for the tablet and capsule. However, the Cmaxvalues of tizanidine achieved if administered with food were increased by 30% for the tablet but decreased by 20% for the capsule. Under fed conditions, the capsule was ≈80% bioavailable relative to the tablet. | ||
Using tizanidine together with caffeine is, in general, not recommended. Combining these medications may significantly increase the blood levels and effects of tizanidine. | ||
Gabapentin | High-protein food increased the AUC and Cmaxby 26% and 32%, respectively [41]. | Take extended release tablet with evening meal. Swallow whole; do not chew, crush, or split. |
No significant effects on the rate or extent of absorption of the immediate-release tablet were noted. The rate and extent of absorption of the extended-release tablet was increased. | ||
Carbamazepine | Serum levels of carbamazepine may be increased if taken with food and/or grapefruit juice. | Extended-release tablets should be administered with meals; swallow whole, do not crush or chew. |
SSRIs | Paroxetine: peak concentration is increased, but bioavailability is not significantly altered by food. | Â |
Sertraline: average peak serum levels may be increased if taken with food. |