Figure 1

Change in hand tapping over time by sex. Individual profiles for 237 patients (A) and the population averages with 95% CI (dashed lines; B). On average, patients performed 5.1 fewer taps each year (p < 0.0001), but there were large differences in hand tapping scores between patients. This can be seen in panel (C), which shows the estimated annual change for each individual. The population mean is indicated with the triangle on the x-axis.