Core analysis | Both sexes | Both sexes | Women | Men | ||
---|---|---|---|---|---|---|
Study population, incidence period | All ages both sexes | Age at onset <35y | Age at onset ≥35y | Age at onset ≥35y | Age at onset ≥35y | |
First author and reference | Lorraine 1990-2002 | 1 | 1 | 1 | 1 | 1 |
Debouverie 2007 [31] | ||||||
Reggio Emilia 85-1989 | 0.33 | 0.37 | 0.25 | 0.28 | 0.18 | |
Guidetti 1995 [36] | (0.24-0.45) | (0.29-0.48) | (0.17-0.36) | (0.19-0.42) | (0.09-0.37) | |
UK cohort 1993-2000 | 1.22 | 0.57 | 1.66 | 1.59 | 1.55 | |
Alonso 2007 [48] | (0.94-1.59) | (0.48-0.66) | (1.30-2.13) | (1.28-1.96) | (1.03-2.35) | |
Catania 1990-1999 | 0.98 | 0.90 | 0.87 | 0.84 | 0.90 | |
Nicoletti 2005 [32] | (0.72-1.32) | (0.72-1.12) | (0.63-1.20) | (0.61-1.17) | 0.53-1.50) | |
Faroe Islands 86-2007 | 0.94 | 0.83 | 0.91 | 0.80 | 1.02 | |
Joensen 2011 [19] | (0.63-1.39) | (0.55-1.25) | (0.57-1.48) | (0.45-1.45) | (0.49-2.10) | |
Västerbotten 88-1997 | 1.07 | 1.03 | 1.00 | 0.96 | 1.02 | |
Sundström 2003 [37] | (0.79-1.46) | (0.81-1.32) | (0.72-1.39) | (0.68-1.36) | (0.61-1.70) | |
Ferrara 90-2003 | 0.74 | 0.79 | 0.64 | 0.74 | 0.49 | |
Granieri 2007 [34] | (0.55-0.99) | (0.65-0.97) | (0.48-0.86) | (0.55-0.98) | (0.29-0.81) | |
San Marino 90-2005 | 1.44 | 1.43 | 1.19 | 1.34 | 0.81 | |
Granieri 2008 [35] | (0.93-2.23) | (0.92-2.23) | (0.66-2.15) | (0.71-2.54) | (0.25-2.61) | |
Catania 2000-2004 | 1.39 | 1.19 | 1.43 | 1.06 | 2.07 | |
Nicoletti 2011 [10] | (1.01-1.91) | (0.90-1.57) | (1.01-2.00) | (0.72-1.57) | (1.26-3.38) | |
West Indies 1992-2007 | 0.21 | 0.19 | 0.21 | 0.26 | 0.11 | |
Cabre 2009 [8] | (0.16-0.29) | (0.15-0.25) | (0.15-0.29) | (0.19-0.35) | (0.06-0.22) | |
Age-groups | 0-14y | 0.01 | 0.01 | - | - | - |
(0.008-0.02) | (0.008-0.02) | |||||
15-24y | 0.50 | 0.47 | - | - | - | |
(0.39-0.64) | (0.42-0.52) | |||||
25-34y | 1 | 1 | - | - | - | |
35-44y | 0.84 | - | 1 | 1 | 1 | |
(0.67-1.04) | ||||||
45-54y | 0.56 | - | 0.66 | 0.61 | 0.71 | |
(0.44-0.71) | (0.55-0.78) | (0.52-0.71) | (0.52-0.97) | |||
55-64y | 0.19 | - | 0.21 | 0.17 | 0.29 | |
(0.14-0.25) | (0.17-0.27) | (0.14-0.22) | (0.20-0.44) | |||
≥65y | 0.02 | - | 0.02 | 0.02 | 0.03 | |
(0.01-0.04) | (0.01-0.04) | (0.01-0.04) | (0.01-0.06) | |||
Sex (reference men) | 2.19 | 2.81 | 1.96 | - | - | |
(1.87-2.57) | (2.51-3.14) | (1.67-2.31) | ||||
Mid time point incidence period * | 1.09 | 1.06 | 1.12 | 1.07 | 1.20 | |
(1.04-1.15) | (1.01-1.12) | (1.05-1.20) | (0.99-1.15) | (1.07-1.34) | ||
Latitude degrees* | 1.04 | 1.03 | 1.05 | 1.04 | 1.06 | |
(1.03-1.05) | (1.02-1.04) | (1.03-1.06) | (1.02-1.05) | (1.03-1.08) | ||
Diagnostic criteria* | Poser | 1 | 1 | 1 | 1 | 1 |
Other than Poser’s (McAlpine) MRI data not considered | 0.73 | 0.71 | 0.77 | 0.59 | 0.99 | |
(0.41-1.30) | (0.40-1.26) | (0.35-1.67) | (0.25-1.41) | (0.25-3.87) | ||
McDonald or Poser and MacDonald including MRI evidence of spread | 0.68 | 0.43 | 0.94 | 1.06 | 0.76 | |
(0.55-0.85) | (0.35-0.53) | (0.71-1.22) | (0.80-1.41) | (0.49-1.26) |