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Table 1 Multimodal criteria for the detection of abnormal findings in the internal jugular veins and in azygos vein/vertebral veins by using 2 noninvasive and 2 invasive imaging techniques

From: Multimodal noninvasive and invasive imaging of extracranial venous abnormalities indicative of CCSVI: Results of the PREMiSe pilot study

Vein territory

DS criteria for abnormal findings

MRV criteria for abnormal findings

CV criteria for abnormal findings

IVUS criteria for abnormal findings

IJVs

- VH criteria 1 - presence of reflux/bidirectional flow in both sitting and supine positions

- Absent or pinpoint flow on axial TOF or TRICKS

- presence of significant stenosis (defined as venous lumen reduction ≥50 %)

- presence of significant stenosis (defined as venous lumen reduction ≥50 %)

and/or

with or without

with or without

and/or

- VH criteria 3 - presence of B-mode abnormalities (web, flap, membrane, malformed valve, septum) or CSA ≤0.3 cm2

- presence of collateral veins (external jugular veins, anterior jugular veins, facial veins, thyroid veins and deep cervical veins)

- presence of collateral veins (either epidural plexus or anterior and external jugular veins, not along the spinal cord)

- presence of various intra-luminal defects (webs, fibrotic annulus-like constrictions, flaps, septa, multiple channels)

and/or

  

and/or

- VH criteria 4 - absence of detectable flow

  

- presence of IHFD and DPL

and/or

  

and/or

- VH criteria 5- negative CSA

  

- reduced respiratory pulsatility

Azygos vein/ VVs

- VH criteria 1 - presence of reflux/bidirectional flow in both sitting and supine positions in VVs

- Absence of detectable flow in VVs

- presence of significant stenosis (defined as venous lumen reduction ≥50 %) in azygos vein

- presence of significant stenosis (defined as venous lumen reduction ≥50 %) in azygos vein

and/or

 

with or without

and/or

- VH criteria 4 - absence of detectable flow in VVs

 

- presence of collateral veins (either epidural or other collaterals)

- presence of various intra-luminal defects (webs, fibrotic annulus-like constrictions, flaps, septa, multiple channels)

   

and/or

   

- presence of IHFD and DPL

   

and/or

    

- reduced respiratory pulsatility

  1. Legend: IJVs - internal jugular veins; VVs - vertebral veins; DS - Doppler sonography: MRV - magnetic resonance venography; CV - catheter venography; IVUS - intravascular ultrasound; VH - venous hemodynamic criteria; CSA - cross-sectional area; IHFD - intra-luminal hyperechoic filling defect; DPL - double parallel lumen.