Identification of genetic contribution to ischemic stroke by screening of single nucleotide polymorphisms in stroke patients by using a case control study design

Table 1 Location and characterization of polymorphisms to be studied

S. No.	Gene	Polymorphism	Role in mechanism of stroke
1.	APOE	Epsilon 2/3, epsilon 3/3, or epsilon 3/4	Arthrosclerosis
2.	MTHFR	C677T	Arthrosclerosis, venous thrombosis
3.	ENOS	G894T	Arthrosclerosis
4.	Factor V Leiden	1691G>A (Arg506Gln)	Venous thromboembolism
5.	CYP4F2	1347 G/A	Vasoconstriction, increase in vascular tone
6.	beta-fibrinogen	(C₁₄₈→T)	Carotid arthrosclerosis
7.	Phosphodiesterase 4D (PDE4D)	SNPs 45 (rs12188950), SNP 83 (rs 966221) and SNP 87 (rs 2910829),	Arthrosclerosis

ISSN: 1471-2377