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Table 2 Frequencies and associations of TNF-α genotypes in patients with spontaneous deep intracerebral hemorrhage (SDICH) and controls

From: Association of TNF-α gene with spontaneous deep intracerebral hemorrhage in the Taiwan population: a case control study

 

Males (n= 403)

Females (n = 225)

Total

SNP

SDICH

(n = 177)

Controls

(n = 226)

P-Value,

OR (95% CI)

SDICH

(n = 83)

Controls

(n = 142)

P-Value,

OR (95% CI)

P-Value,

OR (95% CI)

T-1031C

  

P = 0.03,

1.9 (1.1 to 3.4)

  

P = 0.06,

0.5 (0.3 to 1.02)

P = 0.65,

1.1 (0.7 to 1.7)

TT

119 (67.2)

169 (74.8)

 

52 (62.7)

86 (60.6)

  

TC

48 (27.1)

55 (24.3)

 

31 (37.4)

49 (34.5)

  

CC

10 (5.7)

2 (0.9)

 

0 (0.0)

7 (4.9)

  

C-863A

  

P = 0.09,

1.6 (0.9 to 2.7)

  

P = 0.03,

0.5 (0.2 to 0.9)

P = 0.99,

1.0 (0.7 to 1.5)

CC

120 (67.8)

163 (72.1)

 

54 (65.1)

85 (59.9)

  

CA

46 (26.0)

59 (26.1)

 

28 (33.7)

49 (34.5)

  

AA

11 (6.2)

4 (1.8)

 

1 (1.2)

8 (5.6)

  

C-857T

  

P = 0.20,

0.7 (0.4 to 1.2)

  

P = 0.21,

1.6 (0.8 to 3.3)

P = 0.86,

0.9 (0.6 to 1.5)

CC

132 (74.6)

163 (72.1)

 

52 (62.7)

116 (81.7)

  

CT

43 (24.3)

59 (26.1)

 

30 (36.1)

22 (15.5)

  

TT

2 (1.1)

4 (1.8)

 

1 (1.2)

4 (2.8)

  

G-308A

  

P = 0.005,

2.6 (1.3 to 5.3)

  

P = 0.18,

0.6 (0.2 to 1.3)

P = 0.19,

1.4 (0.8 to 2.4)

GG

129 (72.9)

190 (84.1)

 

67 (80.7)

104 (73.2)

  

GA

44 (24.9)

33 (14.6)

 

15 (18.1)

37 (26.1)

  

AA

4 (2.3)

3 (1.3)

 

1 (1.2)

1 (0.7)

  
  1. Values are n (%). OR: Odds ratio; CI: confidence interval. Logistic regression analyses, adjusting for age, sex, BMI, hypertension, total cholesterol level, and alcohol use in an additive model. P-values in bold were empirical p-values that estimated by permutation of 1000 replicates.
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