From: The genetic basis of multiple sclerosis: a model for MS susceptibility
Number of Susceptibility Genes Required (n) | |||||||
---|---|---|---|---|---|---|---|
5 | 10 | 11 | 12 | 13 | 14 | 15 | |
Frequency of Susceptibility (r) | Predicted Concordance in Non-twin Siblings (100% of Genes Dominant) | ||||||
r = 0.25 | 12.6% | 13.2% | 13.2% | 13.2% | 13.1 - 13.4% | 13.1 - 13.4% | 13.0 - 13.4% |
r = 0.33 | 10.9% | 10.7% | 9.8 - 11.4% | 10.2% | 10.7% | 10.3 - 11.6% | 9.9 - 11.3% |
r = 0.5 | 8.5% | 7.9 - 9.1% | 7.7 - 8.9% | 6.9 - 9.3% | 7.5 - 8.6% | 8.0 - 9.0% | 7.3 - 8.4% |
r = 1 | 7.4 - 8.2% | 6.4 - 7.6% | 6.3 - 7.4% | 6.6 - 7.6% | 6.3 - 7.3% | 6.5 - 7.5% | 6.2 - 7.2% |
r = 2 | 6.6 - 8.0% | 6.4 - 7.5% | 6.4 - 7.1% | 6.2 - 7.2% | 6.1 - 7.0% | 6.2 - 6.8% | 6.0 - 6.9% |
r = 4 | 6.7 - 7.9% | 6.3 - 7.3% | 6.1 - 7.1% | 6.2 - 7.0% | 6.1 - 6.9% | 6.0 - 6.9% | 6.0 - 6.8% |
r = 8 | 6.6 - 7.9% | 6.3 - 7.2% | 6.2 - 7.1% | 6.1 - 7.0% | 6.0 - 6.9% | 6.0 - 6.8% | 6.0 - 6.7% |
r = 16 | 6.6 - 7.9% | 6.3 - 7.2% | 6.1 - 7.0% | 6.1 - 6.9% | 6.0 - 6.8% | 6.0 - 6.8% | 5.9 - 6.7% |
Frequency of Susceptibility (r) | Predicted Concordance in Non-twin Siblings (100% of Genes Recessive) | ||||||
r = 0.25 | 12.6% | 13.2% | 13.2% | 13.1% | 13.1- 13.4% | 13.1 - 13.4% | 13.2 - 13.4% |
r = 0.33 | 10.8% | 10.1% | 9.6 - 11.3% | 9.1 - 10.9% | 10.5% | 10.1 - 11.5% | 9.7 - 11.2% |
r = 0.5 | 8.1% | 6.4 - 7.8% | 7.0 - 8.2% | 6.2 - 8.6% | 6.7 - 7.9% | 7.2 - 8.3% | 6.5 - 7.6% |
r = 1 | 6.4 - 7.2% | 5.2 - 6.3% | 4.8 - 5.9% | 5.0 - 6.0% | 4.6 - 5.6% | 4.8 - 5.7% | 4.5 - 5.4% |
r = 2 | 5.0 - 6.5% | 4.1 - 5.1% | 4.1 - 4.8% | 3.9 - 4.8% | 3.7 - 4.5% | 3.7 - 4.3% | 3.5 - 4.3% |
r = 4 | 4.8 - 6.0% | 3.5 - 4.4% | 3.3 - 4.2% | 3.3 - 4.0% | 3.1 - 3.8% | 3.0 - 3.7% | 2.8 - 3.5% |
r = 8 | 4.3 - 5.7% | 3.1 - 4.0% | 3.0 - 3.7% | 2.8 - 3.5% | 2.6 - 3.3% | 2.5 - 3.1% | 2.4 - 3.0% |
r = 16 | 4.0 - 5.4% | 2.8 - 3.6% | 2.7 -3.4% | 2.5 - 3.2% | 2.3 - 3.0% | 2.2 - 2.8% | 2.1 - 2.6% |