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Neurocritical care

This section covers life-threatening diseases of the central or peripheral nervous systems. Topics include, but are not limited to, coma, status epilepticus, intracranial hemorrhages, neurotrauma, delirium, metabolic encephalopathies, severe stroke, anoxic-ischemic encephalopathy, central nervous system infections and inflammations, Guillain-Barre syndrome, myasthenia gravis crises, intoxications and withdrawal states.

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  2. Prolonged disorders of consciousness (PDOC) may occur after severe brain injury. Two diagnostic entities are distinguished within PDOC: unresponsive wakefulness syndrome (UWS, previously known as vegetative st...

    Authors: Danielle M. F. Driessen, Cecile M. A. Utens, Gerard M. Ribbers, Willemijn S. van Erp and Majanka H. Heijenbrok-Kal

    Citation: BMC Neurology 2021 21:69

    Content type: Study protocol

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  3. During medical imaging, cystic radiation encephalopathy and brain metastasis are difficult to differentiate, and hence they are easily misdiagnosed. To our knowledge, a nasopharyngeal carcinoma recurrence afte...

    Authors: Xuhui Chen, Lijie Ren, Guozhen Qiu and Liming Cao

    Citation: BMC Neurology 2021 21:59

    Content type: Case report

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  5. The aim of the study was to determine the role of the Coma Recovery Scale-Revised (CRS-R) in the prediction of functional status at the end of neurological early rehabilitative treatment.

    Authors: Melanie Boltzmann, Simone B. Schmidt, Christoph Gutenbrunner, Joachim K. Krauss, Martin Stangel, Günter U. Höglinger, Claus-W. Wallesch and Jens D. Rollnik

    Citation: BMC Neurology 2021 21:44

    Content type: Research article

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  6. To investigate the feasibility of intracranial pressure (ICP) monitoring after traumatic brain injury (TBI) by electromagnetic coupling phase sensing, we established a portable electromagnetic coupling phase s...

    Authors: Gen Li, Wang Li, Jingbo Chen, Shuanglin Zhao, Zelin Bai, Qi Liu, Qi Liao, Minglian He, Wei Zhuang, Mingsheng Chen, Jian Sun and Yujie Chen

    Citation: BMC Neurology 2021 21:26

    Content type: Research article

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  7. Status epilepticus (SE) is a common neurological emergency condition that especially affects the elderly and old population. Older people with SE frequently have non-convulsive SE (NCSE) and are also at specia...

    Authors: Annekatrin Müller, Anett Schmiedeknecht, Meinhard Mende, Carolin Awissus, Felix Rosenow, Hajo Hamer and Joseph Classen

    Citation: BMC Neurology 2020 20:438

    Content type: Study protocol

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  11. Recent studies regarding the effects of erythropoietin (EPO) for treating traumatic brain injury (TBI) have been inconsistent. This study conducts a meta-analysis of randomized controlled trials (RCTs) to asse...

    Authors: Motao Liu, Amy J. Wang, Yu Chen, Gexin Zhao, Zhifeng Jiang, Xinbang Wang, Dongliang Shi, Tiansong Zhang, Bomin Sun, Hua He, Ziv Williams and Kejia Hu

    Citation: BMC Neurology 2020 20:399

    Content type: Research article

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  12. Outcome prediction for patients with disorders of consciousness (DOC) is essential yet challenging. Evidence showed that patients with DOC lasting 1 year or longer after a brain injury were less likely to reco...

    Authors: Xiaoxia Li, Xufei Tan, Pinyi Wang, Xiaohua Hu, Yan Dong, Xiaotong Zhang and Benyan Luo

    Citation: BMC Neurology 2020 20:396

    Content type: Case report

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  13. To investigate whether the administration of intravenous propofol before endotracheal suctioning (ES) in patients with severe brain disease can reduce the sputum suction response, improve prognosis, and accele...

    Authors: Menghang Wu, Xiaorong Yin, Maojun Chen, Yan Liu, Xia Zhang, Tingting Li, Yujuan Long, Xiaomei Wu, Lihui Pu, Maojie Zhang, Zhi Hu and Ling Ye

    Citation: BMC Neurology 2020 20:394

    Content type: Research article

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  14. Methamphetamine use is an emerging risk factor for intracerebral hemorrhage (ICH). The aim of this study was to investigate the use of urine drug screen (UDS) for identifying methamphetamine-associated ICH.

    Authors: Sahar Osman, Zhu Zhu, Mark Farag, Leonid Groysman, Cyrus Dastur, Yama Akbari, Sara Stern-Nezer, Dana Stradling and Wengui Yu

    Citation: BMC Neurology 2020 20:392

    Content type: Research article

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  16. Ageing is associated with worse treatment outcome after traumatic brain injury (TBI). This association may lead to a self-fulfilling prophecy that affects treatment efficacy. The aim of the current study was t...

    Authors: Ola Skaansar, Cathrine Tverdal, Pål Andre Rønning, Karoline Skogen, Tor Brommeland, Olav Røise, Mads Aarhus, Nada Andelic and Eirik Helseth

    Citation: BMC Neurology 2020 20:376

    Content type: Research article

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  18. Percutaneous dilatational tracheostomy (PDT) has become a widely performed technique in neurocritical care, which is however known to be accompanied by some risks to the patient. The aim of this pilot study wa...

    Authors: Vera Spatenkova, Eckhard Teschner and Jaroslav Jedlicka

    Citation: BMC Neurology 2020 20:374

    Content type: Research article

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  19. For large hemispheric infarction (LHI), malignant cerebral edema (MCE) is a life-threatening complication with a mortality rate approaching 80%. Establishing a convenient prediction model of MCE after LHI is v...

    Authors: Wenzhe Sun, Guo Li, Yang Song, Zhou Zhu, Zhaoxia Yang, Yuxi Chen, Jinfeng Miao, Xiaoyan Song, Yan Lan, Xiuli Qiu, Suiqiang Zhu and Yebin Fan

    Citation: BMC Neurology 2020 20:360

    Content type: Research article

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  20. Immune-mediated mechanisms substantially contribute to the Rasmussen encephalitis (RE) pathology, but for unknown reasons, immunotherapy is generally ineffective in patients who have already developed intracta...

    Authors: Zuzana Liba, Martina Vaskova, Josef Zamecnik, Jana Kayserova, Hana Nohejlova, Matyas Ebel, Jan Sanda, Gonzalo Alonso Ramos-Rivera, Klara Brozova, Petr Liby, Michal Tichy and Pavel Krsek

    Citation: BMC Neurology 2020 20:359

    Content type: Research article

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  21. In acute large anterior circulation infarct patients with large core volume, we evaluated the role of optic nerve sheath diameter (ONSD) change rates in prediction of malignant progression.

    Authors: Seong-Joon Lee, Mun Hee Choi, Sung Eun Lee, Ji Hyun Park, Bumhee Park, Jin Soo Lee and Ji Man Hong

    Citation: BMC Neurology 2020 20:354

    Content type: Research article

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  22. Posterior reversible encephalopathy syndrome (PRES) is a rare neurological condition with many associated risk factors. The presentation varies and consists of seizures, impaired visual acuity or visual field ...

    Authors: Elad Barber, Rijini Nugzar, Vitaly Finkelshtein, Alexander Puzhevsky and Tally Levy

    Citation: BMC Neurology 2020 20:330

    Content type: Case report

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  23. Listeria monocytogenes is an opportunistic pathogen of the central nervous system commonly associated with impaired cell-mediated immunity. We hereby present a case of adult neurolisteriosis where the only immuno...

    Authors: Kostas Patas, Theodoros Mavridis, Katerina Psarra, Vassilis E. Papadopoulos, Georgia Mandilara, Alexandra Tsirogianni, Sophia Vassilopoulou and Stylianos Chatzipanagiotou

    Citation: BMC Neurology 2020 20:323

    Content type: Case report

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  24. Acceptance and Commitment Therapy (ACT), as a type of behavioral therapy, attempts to respond to changes in people’s performance and their relationship to events. ACT can affect sleep quality by providing tech...

    Authors: Nader Salari, Habibolah Khazaie, Amin Hosseinian-Far, Behnam Khaledi-Paveh, Hooman Ghasemi, Masoud Mohammadi and Shamarina Shohaimi

    Citation: BMC Neurology 2020 20:300

    Content type: Research article

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  26. COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of ...

    Authors: Shelli Farhadian, Laura R. Glick, Chantal B. F. Vogels, Jared Thomas, Jennifer Chiarella, Arnau Casanovas-Massana, Jing Zhou, Camila Odio, Pavithra Vijayakumar, Bertie Geng, John Fournier, Santos Bermejo, Joseph R. Fauver, Tara Alpert, Anne L. Wyllie, Cynthia Turcotte…

    Citation: BMC Neurology 2020 20:248

    Content type: Case report

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  27. Mechanical ventilation (MV) with positive end-expiratory pressure (PEEP) is commonly applied in patients with severe traumatic brain injury (sTBI). However, the individual responsiveness of intracranial pressu...

    Authors: Hong Peng Li, Ying Ni Lin, Zhi Hui Cheng, Wei Qu, Liu Zhang and Qing Yun Li

    Citation: BMC Neurology 2020 20:234

    Content type: Research article

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  28. Intracranial necrotizing granulomatous space-occupying lesions are sparsely reported in literature. Variability in presenting symptomatology and radiographic features makes diagnostic work-up difficult.

    Authors: Kerilyn N. Godbe, Brian F. Saway, Evin L. Guilliams, John J. Entwistle and Robert W. Jarrett Jr

    Citation: BMC Neurology 2020 20:230

    Content type: Case report

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  29. Recent studies have examined hypertrophic pachymeningitis as an IgG4-RD. However, there are no reports of immunoglobulin G4 (IgG4)-related hypertrophic pachymeningitis with polycystic subdural hygroma.

    Authors: Kazumichi Ota, Yoshihiko Nakazato, Risa Okuda, Ryu Yokoyama, Hitoshi Kawasaki, Naotoshi Tamura and Toshimasa Yamamoto

    Citation: BMC Neurology 2020 20:228

    Content type: Case report

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  31. We evaluated severe pain-related adverse events (SAE) during the percutaneous dilatational tracheostomy (PDT) procedure performed by a neurointensivist and compared the outcomes with that of conventional surgi...

    Authors: Yong Oh Kim, Chi Ryang Chung, Chi-Min Park, Gee Young Suh and Jeong-Am Ryu

    Citation: BMC Neurology 2020 20:223

    Content type: Research article

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  32. Thrombocytopenia (TP) has been shown to be an independent predictor of mortality in the intensive care unit (ICU) patients. Studies are lacking in the neurological ICU (NICU) population. The aim was to evaluat...

    Authors: Dawei Zhou, Zhimin Li, Lei Wu, Guangzhi Shi and Jianxin Zhou

    Citation: BMC Neurology 2020 20:220

    Content type: Research article

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  33. It is not well defined whether Guillain–Barré syndrome (GBS) patients with elevated serum creatine kinase (CK) levels have characteristic clinical features and are related to the subgroups of GBS.

    Authors: Takafumi Hosokawa, Hideto Nakajima, Taiki Sawai, Yoshitsugu Nakamura, Eri Sano, Akihiro Tsukahara, Kiichi Unoda, Shimon Ishida, Sadaki Sakane, Fumiharu Kimura and Shigeki Arawaka

    Citation: BMC Neurology 2020 20:214

    Content type: Research article

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  34. Routine test of cerebrospinal fluid (CSF), such as glucose concentrations, chloride ion, protein and leukocyte, as well as color, turbidity and clot, were important indicators for intracranial infection. Howev...

    Authors: Tiantian Zhai, Zhong lian Fu, Yan bing Qiu, Qiang Chen, Dong Luo and Kaisen Chen

    Citation: BMC Neurology 2020 20:213

    Content type: Research article

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  35. Concussion is the most common type of TBI, yet reliable objective measures related to these injuries and associated recovery processes remain elusive, especially in military personnel. The purpose of this stud...

    Authors: Katie A. Edwards, Jessica M. Gill, Cassandra L. Pattinson, Chen Lai, Misha Brière, Nicholas J. Rogers, Denise Milhorn, Jonathan Elliot and Walter Carr

    Citation: BMC Neurology 2020 20:209

    Content type: Research article

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  36. Cerebellar degeneration as a consequence of a malignancy is a rare condition most commonly related to the presence of anti-Yo, anti-Hu, and anti-Tr/DNER antibodies. In recent years, several reports have indica...

    Authors: Philipp A. Loehrer, Lars Timmermann, Anika Pehl, Corinna I. Bien, Andreas Pfestroff and David J. Pedrosa

    Citation: BMC Neurology 2020 20:208

    Content type: Case report

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  37. We investigated the clinical course of patients with prolonged disorders of consciousness (PDoC), predictors of emergence from PDoC (EDoC), and the temporal dynamics of six neurobehavior domains based on the J...

    Authors: Hoo Young Lee, Jung Hyun Park, Ae Ryoung Kim, Misun Park and Tae-Woo Kim

    Citation: BMC Neurology 2020 20:198

    Content type: Research article

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  38. To explore the underlying mechanisms leading to the occurrence of hyponatremia and enhanced urinary sodium excretion in brain trauma patients using sodium balance and urinary biochemical analysis.

    Authors: Alexandre Lannou, Cedric Carrie, Sebastien Rubin, Gregoire Cane, Vincent Cottenceau, Laurent Petit and Matthieu Biais

    Citation: BMC Neurology 2020 20:190

    Content type: Research article

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  39. To explore the feasibility of the metrics of diffusion kurtosis imaging (DKI) for investigations of the microstructural changes of spinal cord injury in patients with degenerative cervical myelopathy (DCM) and...

    Authors: Zhuohang Liu, Bingyang Bian, Gang Wang, Cheukying Tian, Zhenshan Lv, Zhiqing Shao and Dan Li

    Citation: BMC Neurology 2020 20:185

    Content type: Research article

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  40. Narcolepsy is a rare chronic sleep disorder that typically begins in youth. Excessive daytime sleepiness is the main disabling symptom, but the disease is often associated with severe endocrine-metabolic and p...

    Authors: Francesca Ingravallo, Luca Vignatelli, Uberto Pagotto, Stefano Vandi, Monica Moresco, Anastasia Mangiaruga, Claudia Oriolo, Corrado Zenesini, Fabio Pizza and Giuseppe Plazzi

    Citation: BMC Neurology 2020 20:176

    Content type: Study protocol

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  42. Lithium is primarily used to treat bipolar disorder and is known to cause several acute neurological complications. Reversible splenial lesions (RSLs) may be evident in antiepileptic drug toxicity or withdrawa...

    Authors: Han Uk Ryu, Ji Yeon Chung, Byoung-Soo Shin and Hyun Goo Kang

    Citation: BMC Neurology 2020 20:164

    Content type: Case report

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  43. Intracranial hypotension is a disorder characterized by low cerebrospinal fluid (CSF) pressure typically caused by loss of CSF. Although some mechanisms account for the CSF leakage have been elucidated, spinal...

    Authors: Chihiro Akiba, Hideki Bandai, Yoshitaka Ito, Tsuyoshi Maeda, Keisuke Yamaguchi, Madoka Nakajima and Masakazu Miyajima

    Citation: BMC Neurology 2020 20:151

    Content type: Case report

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  44. Hydrocephalus is a common, life threatening complication of human immunodeficiency virus (HIV)-related central nervous system opportunistic infection which can be treated by insertion of a ventriculoperitoneal...

    Authors: James J. M. Loan, Michael T. C. Poon, Steven Tominey, Ncedile Mankahla, Graeme Meintjes and A. Graham Fieggen

    Citation: BMC Neurology 2020 20:141

    Content type: Research article

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  45. We imaged the corticospinal tract (CST) and corticoreticular pathway (CRP) using diffusion tensor tractography (DTT) to evaluate the cause of muscle weakness in a patient who was exposed to high-voltage electr...

    Authors: Mathieu Boudier-Revéret, Ming-Yen Hsiao, Shaw-Gang Shyu and Min Cheol Chang

    Citation: BMC Neurology 2020 20:130

    Content type: Case report

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  46. Reversible splenial lesion syndrome (RESLES) is known to cause severe psychiatric symptoms but is also a very rare clinical disease in which the specific aetiology is unknown. According to current reports, the...

    Authors: Song Hu, Xinyue Hou, Shuhao Liu, Chunxiao Fei, Lingyan Zhou, Ang Xing, Junqing Zhang, Chunming Yong and Xiaomeng Wang

    Citation: BMC Neurology 2020 20:122

    Content type: Case report

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  47. This systematic review and meta-analysis aimed to synthesize the latest evidence on the efficacy and safety of tranexamic acid (TXA) on traumatic brain injury (TBI).

    Authors: Julius July and Raymond Pranata

    Citation: BMC Neurology 2020 20:119

    Content type: Research article

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  48. Acute hyperammonemia without signs of common causes in the elderly might be challenging to identify. We report the oldest case known to date of a female patient with late onset ornithine carbamyltransferase de...

    Authors: Justus Marquetand, Peter Freisinger, Tobias Lindig, Sebastian Euler, Michael Gasser and Dietrich Overkamp

    Citation: BMC Neurology 2020 20:118

    Content type: Case report

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  50. Road traffic accidents are known to be the main cause of traumatic brain injury (TBI). TBI is also a leading cause of death and disability. This study, by means of the idiographic approach (single-case experim...

    Authors: Samir Al-Adawi, Aziz Al-Naamani, Sanjay Jaju, Yahya M. Al-Farsi, Atsu S. S. Dorvlo, Ali Al-Maashani, Sara S. H. Al-Adawi, Ahmed A. Moustafa, Nasser Al-Sibani, Musthafa M. Essa, David T. Burke and M. Walid Qoronfleh

    Citation: BMC Neurology 2020 20:103

    Content type: Research article

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