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Movement disorders

This section covers all types and aspects of movement disorders. Topics of include, but are not limited to, Parkinson's Disease, transcranial magnetic stimulation, spasticity, dyskinesia, movement disorders, rehabilitation and spinal cord injury.

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  1. Parkinsonian variant of multiple system atrophy is a neurodegenerative disorder frequently misdiagnosed as Parkinson’s disease. No early imaging biomarkers currently differentiate these disorders.

    Authors: Rita Moiron Simões, Ana Castro Caldas, Joana Grilo, Daisy Correia, Carla Guerreiro, Patrícia Pita Lobo, Anabela Valadas, Marguerita Fabbri, Leonor Correia Guedes, Miguel Coelho, Mario Miguel Rosa, Joaquim J. Ferreira and Sofia Reimão

    Citation: BMC Neurology 2020 20:432

    Content type: Research article

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  2. Parkinson’s disease is the second most common long-term chronic, progressive, neurodegenerative disease, affecting more than 10 million people worldwide. There has been a rising interest in wearable devices fo...

    Authors: Ghayth AlMahadin, Ahmad Lotfi, Eva Zysk, Francesco Luke Siena, Marie Mc Carthy and Philip Breedon

    Citation: BMC Neurology 2020 20:419

    Content type: Research article

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  3. Cerebral Palsy (CP) is a group of disorders that affect the development of movement and posture. CP results from injuries to the immature brain during the prenatal, perinatal, or postnatal stage of development...

    Authors: Diana Tajik-Parvinchi, Andrew Davis, Sophia Roth, Peter Rosenbaum, Sarah N. Hopmans, Aya Dudin, Geoffrey Hall and Jan Willem Gorter

    Citation: BMC Neurology 2020 20:388

    Content type: Research article

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  4. Parkinson’s disease (PD) is a common neurodegenerative condition associated with a wide range of motor and non-motor symptoms. There has been increasing interest in the potential benefit of performing arts as ...

    Authors: Maxwell S. Barnish and Susannah M. Barran

    Citation: BMC Neurology 2020 20:371

    Content type: Research article

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  5. Cognitive impairment may be correlated with cardiovascular dysautonomia, including blood pressure (BP) dysregulation, in Parkinson’s disease (PD), but the association between these factors in dementia with Lew...

    Authors: Hisayoshi Oka, Tadashi Umehara, Atsuo Nakahara and Hiromasa Matsuno

    Citation: BMC Neurology 2020 20:350

    Content type: Research article

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  6. Neurologists play an essential role in facilitating the patient’s process of living with Parkinson’s disease (PD). The Living with Chronic Illness Scale-PD (LW-CI-PD) is a unique available clinical tool that e...

    Authors: Leire Ambrosio, Carmen Rodriguez-Blazquez, Alba Ayala and Maria João Forjaz

    Citation: BMC Neurology 2020 20:346

    Content type: Research article

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  7. Studies report rates of mild cognitive impairment (MCI) in spinal cord injury (SCI) range between 10 and 60%. This broad estimate of MCI in SCI is most likely a result of: (i) inconsistent operationalization o...

    Authors: Danielle Sandalic, Ashley Craig, Mohit Arora, Ilaria Pozzato, Grahame Simpson, Bamini Gopinath, Jasbeer Kaur, Sachin Shetty, Gerard Weber, Ian Cameron, Yvonne Tran and James Middleton

    Citation: BMC Neurology 2020 20:341

    Content type: Study protocol

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  8. Various wearable devices for objectively evaluating motor symptoms of patients with Parkinson’s disease (PD) have been developed. Importantly, previous studies have suggested protective effects of physical act...

    Authors: Hiroto Ito, Daichi Yokoi, Rei Kobayashi, Hisashi Okada, Yasukazu Kajita and Satoshi Okuda

    Citation: BMC Neurology 2020 20:340

    Content type: Research article

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  9. The progressive neurodegenerative disorder Parkinson disease (PD) is well-established as the second most common neurodegenerative disease. Associations between the sequential risk of PD and gout have been addr...

    Authors: Li-Yu Hu, Albert C. Yang, Shyh-Chyang Lee, Zi-Hong You, Shih-Jen Tsai, Chang-Kuo Hu and Cheng-Che Shen

    Citation: BMC Neurology 2020 20:338

    Content type: Research article

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  10. Cognitive decline and dementia are common in Parkinson’s disease (PD). Cognitive deficits have been linked to the depletion of dopamine in the nigrostriatal pathway, but pharmacological treatments for PD have ...

    Authors: Magdalena Eriksson Domellöf, Lois Walton, Carl-Johan Boraxbekk, David Bäckström, Maria Josefsson, Lars Forsgren and Anna Stigsdotter Neely

    Citation: BMC Neurology 2020 20:337

    Content type: Study protocol

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  11. Anterior spinal cord herniation (aSCH) is a rare cause of myelopathy which may present as pure motor syndrome and mimic other degenerative diseases of the spinal cord. In slowly progressive cases, diagnosis ma...

    Authors: Martin Regensburger, Johannes C. M. Schlachetzki, Jörg Klekamp, Arnd Doerfler and Jürgen Winkler

    Citation: BMC Neurology 2020 20:321

    Content type: Case report

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  12. Parkinson’s disease (PD) causes motor and nonmotor disorders in patients. Unlike aerobic training, potential adaptations from the practice of dance are less understood in PD, particularly compared with better ...

    Authors: Marcela dos Santos Delabary, Elren Passos Monteiro, Rebeca Gimenes Donida, Mariana Wolffenbuttel, Leonardo Alexandre Peyré-Tartaruga and Aline Nogueira Haas

    Citation: BMC Neurology 2020 20:305

    Content type: Research article

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  13. With the growing awareness of restless legs syndrome (RLS), sensory disorders similar to RLS but initially confined to the arms, abdomen, and perineum have been reported. One of them is restless abdomen, which...

    Authors: Xi-Xi Wang, Xiao-Ying Zhu, Zan Wang, Jian-Wei Dong, William G. Ondo and Yun-Cheng Wu

    Citation: BMC Neurology 2020 20:298

    Content type: Research article

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  14. PDSAFE is an individually-tailored, physiotherapist-delivered, balance, strength and strategy training programme aimed at preventing falls among people with Parkinson’s. We evaluated the cost-effectiveness of ...

    Authors: Yiqiao Xin, Ann Ashburn, Ruth M. Pickering, Kim Chivers Seymour, Sophia Hulbert, Carolyn Fitton, Dorit Kunkel, Ioana Marian, Helen C. Roberts, Sarah E. Lamb, Victoria A. Goodwin, Lynn Rochester and Emma McIntosh

    Citation: BMC Neurology 2020 20:295

    Content type: Research article

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  15. The diagnosis of Parkinson’s Disease (PD) remains a challenge and is currently based on the assessment of clinical symptoms. PD is also a heterogeneous disease with great variability in symptoms, disease cours...

    Authors: A. F. Wolters, M. Heijmans, S. Michielse, A. F. G. Leentjens, A. A. Postma, J. F. A. Jansen, D. Ivanov, A. A. Duits, Y. Temel and M. L. Kuijf

    Citation: BMC Neurology 2020 20:292

    Content type: Study protocol

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  16. Dopamine transporter (DAT) imaging may enable clinicians to discriminate idiopathic normal pressure hydrocephalus (iNPH) from other parkinsonian disorders. However, a specific pattern of dopaminergic loss in D...

    Authors: Jeong-Yoon Lee, Soo Bin Park, Mina Lee, Hyunjin Ju, Kayeong Im and Kyum-Yil Kwon

    Citation: BMC Neurology 2020 20:277

    Content type: Research article

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  17. There is growing evidence for proprioceptive dysfunction in patients with Parkinson’s disease (PD). The Lee Silvermann Voice Treatment-BIG therapy (LSVT-BIG), a special training program aiming at an increase o...

    Authors: Manuel Peterka, Thorsten Odorfer, Michael Schwab, Jens Volkmann and Daniel Zeller

    Citation: BMC Neurology 2020 20:276

    Content type: Research article

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  18. In this study, we explored whether the proposed short-echo-time magnitude (setMag) image derived from quantitative susceptibility mapping (QSM) could resemble NM-MRI image in substantia nigra (SN), by quantita...

    Authors: Xue Ling Liu, Li Qin Yang, Feng Tao Liu, Pu-Yeh Wu, Yong Zhang, Han Zhuang, Yong Hong Shi, Jian Wang, Dao Ying Geng and Yu Xin Li

    Citation: BMC Neurology 2020 20:262

    Content type: Research article

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  19. Even though recent research has achieved significant advancement in the development of therapeutic approaches for Wilson’s diseases (WD), the current treatment options available for WD are still limited, espec...

    Authors: Jing Zhang, Lulu Xiao and Wenming Yang

    Citation: BMC Neurology 2020 20:255

    Content type: Research article

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  20. Parkinson’s Disease (PD) is a heterogeneous, progressive neurodegenerative disorder which is characterized by a variety of motor and non-motor symptoms. To date, no disease modifying treatment for PD exists. H...

    Authors: Jeffrey M. Boertien, Sygrid van der Zee, Asterios Chrysou, Marleen J. J. Gerritsen, Nomdo M. Jansonius, Jacoba M. Spikman and Teus van Laar

    Citation: BMC Neurology 2020 20:245

    Content type: Study protocol

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  21. Diffusion tensor imaging (DTI) is an effective method to identify subtle changes to normal-appearing white matter (WM). Here we analyzed the DTI data with other examinations, including motor evoked potentials ...

    Authors: Beike Chen, Qiang Tan, Weikang Zhao, Qiming Yang, Hongyan Zhang, Fabao Gao, Xin Liu, Hua Feng and Dianming Jiang

    Citation: BMC Neurology 2020 20:236

    Content type: Research article

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  22. Palato-pharyngo-laryngeal myoclonus, a variant of palatal myoclonus, is characterized by involuntary rhythmic movements of palatal, pharyngeal, and laryngeal muscles. Symptomatic palatal myoclonus is classical...

    Authors: Jamie L. Fleet, Ronelle Calver, Gihan C. Perera and Zhihui Deng

    Citation: BMC Neurology 2020 20:222

    Content type: Case report

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  23. We investigated the gait characteristics of patients with Parkinson’s disease (PD), under free-living conditions, using a wearable device, and assessed their relationships with global cognitive function and mo...

    Authors: Hiroo Terashi, Takeshi Taguchi, Yuki Ueta, Yoshihiko Okubo, Hiroshi Mitoma and Hitoshi Aizawa

    Citation: BMC Neurology 2020 20:161

    Content type: Research article

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  24. The “hot cross bun” (HCB) sign, a cruciform hyperintensity in the pons on magnetic resonance imaging (MRI), has gradually been identified as a typical finding in multiple system atrophy, cerebellar-type (MSA-C...

    Authors: Atsuhiko Sugiyama, Hajime Yokota, Yoshitaka Yamanaka, Hiroki Mukai, Tatsuya Yamamoto, Shigeki Hirano, Kyosuke Koide, Shoichi Ito and Satoshi Kuwabara

    Citation: BMC Neurology 2020 20:157

    Content type: Research article

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  25. Heart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia. The purpose of this pilot study is to evaluate long-term time-domain analys...

    Authors: V. Arnao, A. Cinturino, S. Mastrilli, C. Buttà, C. Maida, A. Tuttolomondo, P. Aridon and M. D’Amelio

    Citation: BMC Neurology 2020 20:152

    Content type: Research article

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  26. Parkinson disease (PD) is a debilitating and chronic neurodegenerative disease resulting in ambulation difficulties. Natural walking activity often declines early in disease progression despite the relative st...

    Authors: Kerri S. Rawson, James T. Cavanaugh, Cristina Colon-Semenza, Tami DeAngelis, Ryan P. Duncan, Daniel Fulford, Michael P. LaValley, Pietro Mazzoni, Timothy Nordahl, Lisa M. Quintiliani, Marie Saint-Hilaire, Cathi A. Thomas, Gammon M. Earhart and Terry D. Ellis

    Citation: BMC Neurology 2020 20:146

    Content type: Study protocol

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  27. Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late onset, X-linked genetic, neurodegenerative disorder caused by a “premutation (PM)” in the fragile X mental retardation 1 (FMR1) gene. Here we report a...

    Authors: Cuiping Zhao, Yiming Liu, Yihua Wang, Hongyan Li, Bin Zhang, Yaoxian Yue and Jianyuan Zhang

    Citation: BMC Neurology 2020 20:145

    Content type: Case report

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  28. RLS is known as one of the most common movement disorders during pregnancy, which is most aggravated in the third trimester of pregnancy and can affect up to one-third of pregnant women. This study intends to ...

    Authors: Niloofar Darvishi, Alireza Daneshkhah, Behnam Khaledi-Paveh, Aliakbar Vaisi-Raygani, Masoud Mohammadi, Nader Salari, Fateme Darvishi, Alireza Abdi and Rostam Jalali

    Citation: BMC Neurology 2020 20:132

    Content type: Research article

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  29. Progressive supranuclear palsy (PSP) is a rare movement disorder with poor prognosis. This retrospective study aimed to characterize the natural history of PSP and to find predictors of shorter survival and fa...

    Authors: Shi-Shuang Cui, Hua-Wei Ling, Juan-Juan Du, Yi-Qi Lin, Jing Pan, Hai-Yan Zhou, Gang Wang, Ying Wang, Qin Xiao, Jun Liu, Yu-Yan Tan and Sheng-Di Chen

    Citation: BMC Neurology 2020 20:114

    Content type: Research article

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  30. Phospholipase A2 group VI (PLA2G6) mutations associated with neurodegeneration (PLAN) manifest as heterogeneous neurodegenerative disorders with variable ages of onset. The genotype-phenotype correlation is not w...

    Authors: Yung-Tsai Chu, Han-Yi Lin, Pei-Lung Chen and Chin-Hsien Lin

    Citation: BMC Neurology 2020 20:101

    Content type: Case report

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  31. Intracranial neoplasms are an uncommon cause of symptomatic parkinsonism. We here report a patient with an extensive middle and posterior fossa arachnoid cyst presenting with parkinsonism that was treated by n...

    Authors: Bernadette Wimmer, Stephanie Mangesius, Klaus Seppi, Sarah Iglseder, Franziska Di Pauli, Martin Ortler, Elke Gizewski, Werner Poewe and Gregor Karl Wenning

    Citation: BMC Neurology 2020 20:89

    Content type: Case report

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  32. Huntington’s disease (HD), an inherited, often late-onset, neurodegenerative disorder, is considered to be a rare, orphan disease. Research into its genetic correlates and services for those affected are inade...

    Authors: Nikhil Ratna, Nitish L. Kamble, Sowmya D. Venkatesh, Meera Purushottam, Pramod K. Pal and Sanjeev Jain

    Citation: BMC Neurology 2020 20:87

    Content type: Research article

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  33. Parkinson’s disease (PD) is a devastating neurodegenerative disorder. Reduced balance is one of the cardinal symptoms of PD, predisposing people living with PD to experience difficulties with the execution of ...

    Authors: Sofie LaGrone, Conran Joseph, Hanna Johansson, Birgit Enberg and Erika Franzén

    Citation: BMC Neurology 2020 20:50

    Content type: Research article

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  34. Both Deep Brain Stimulation (DBS) and Continuous intrajejunal Levodopa Infusion (CLI) are effective therapies for the treatment of Parkinson’s disease (PD). To our knowledge, no direct head-to-head comparison ...

    Authors: D. van Poppelen, V. Sisodia, R. J. de Haan, M. G. W. Dijkgraaf, P. R. Schuurman, G. J. Geurtsen, A. E. M. Berk, R. M. A. de Bie and J. M. Dijk

    Citation: BMC Neurology 2020 20:40

    Content type: Study protocol

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  35. Alexander disease is a rare neurological disease characterized by progressive spastic quadriparesis and bulbar palsy. Moreover, certain patients with adult-onset Alexander disease were often misdiagnosed as ot...

    Authors: Jongkyu Park, Sung-Tae Park, Jieun Kim and Kyum-Yil Kwon

    Citation: BMC Neurology 2020 20:27

    Content type: Case report

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  36. Parkinson’s disease (PD) and atypical parkinsonisms (APD) have overlapping symptoms challenging an early diagnosis. Diagnostic accuracy is important because PD and APD have different prognosis and response to ...

    Authors: Anna Santaella, H. Bea Kuiperij, Anouke van Rumund, Rianne A. J. Esselink, Alain J. van Gool, Bastiaan R. Bloem and Marcel M. Verbeek

    Citation: BMC Neurology 2020 20:26

    Content type: Research article

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  37. Parkinson’s disease (PD) is a progressive neurodegenerative movement disorder that is characterized by motor symptoms such as tremor, rigidity, slowness of movement and problems with gait. Large-scale meta-ana...

    Authors: Hui Wu, Hui Li, Zhiqiang Shi, Jiajia Tang, Shuya Mei, Tianyi Ai and Zhenzhou He

    Citation: BMC Neurology 2020 20:19

    Content type: Research article

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  38. Pain is a common problem for individuals with cerebral palsy (CP). In Sweden, 95% of children and adolescents with CP are followed in a national follow-up programme (CPUP), which includes data on pain. The pur...

    Authors: Elsa Eriksson, Gunnar Hägglund and Ann I. Alriksson-Schmidt

    Citation: BMC Neurology 2020 20:15

    Content type: Research article

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  39. Active Rehabilitation (AR) is a community peer-based concept for people with spinal cord injury (SCI) that is primarily delivered through brief residential training programmes. Despite a plethora of positive a...

    Authors: Anestis Divanoglou, Tomasz Tasiemski and Sophie Jörgensen

    Citation: BMC Neurology 2020 20:14

    Content type: Study protocol

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  40. Huntington’s disease (HD) is a rare, genetic, neurodegenerative and ultimately fatal disease with no cure or progression-delaying treatment currently available. HD is characterized by a triad of cognitive, beh...

    Authors: Christoph Ohlmeier, Kai-Uwe Saum, Wolfgang Galetzka, Dominik Beier and Holger Gothe

    Citation: BMC Neurology 2019 19:318

    Content type: Research article

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  41. Huntington’s disease (HD) is a progressive, neurological disorder that results in both cognitive and physical impairments. These impairments affect an individual’s gait and, as the disease progresses, it signi...

    Authors: Helia Mahzoun Alzakerin, Yannis Halkiadakis and Kristin D. Morgan

    Citation: BMC Neurology 2019 19:316

    Content type: Research article

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  42. The mechanisms underlying the online modulation of motor speech in Parkinson’s disease (PD) have not been determined. Moreover, medical and rehabilitation interventions for PD-associated motor speech disorder ...

    Authors: Ying Liu, Yuchang Gui, Jincui Hu, Shanshan Liang, Sixia Mo, Yuanfang Zhou, Yujian Li, Fengkun Zhou and Jianwen Xu

    Citation: BMC Neurology 2019 19:309

    Content type: Research article

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  43. Progressive Supranuclear Palsy (PSP) is the most frequent form of atypical Parkinsonism. Although there is preliminary evidence for the benefits of gait rehabilitation, balance training and oculomotor exercise...

    Authors: Susan C. Slade, Martin Underwood, Jennifer L. McGinley and Meg E. Morris

    Citation: BMC Neurology 2019 19:305

    Content type: Research article

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  44. McLeod syndrome is a rare X-linked recessive acanthocytosis associated with neurological manifestations including progressive chorea, cognitive impairment, psychiatric disturbances, seizures, and sensorimotor ...

    Authors: Takenobu Murakami, Dan Abe, Hideyuki Matsumoto, Ryo Tokimura, Mitsunari Abe, Amanda Tiksnadi, Shunsuke Kobayashi, Chikako Kaneko, Yuka Urata, Masayuki Nakamura, Akira Sano and Yoshikazu Ugawa

    Citation: BMC Neurology 2019 19:301

    Content type: Case report

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  45. Parkinson’s disease (PD) affects many physiological systems essential for balance control. Recent studies suggest that intensive and cognitively demanding physical exercise programs are capable of inducing pla...

    Authors: Erika Franzén, Hanna Johansson, Malin Freidle, Urban Ekman, Martin Benka Wallén, Ellika Schalling, Alexander Lebedev, Martin Lövdén, Staffan Holmin, Per Svenningsson and Maria Hagströmer

    Citation: BMC Neurology 2019 19:280

    Content type: Study protocol

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  46. Wilson disease (WD) is genetically induced failure of copper metabolism which can be successfully treated with pharmacological agents. The prognosis for survival in most WD patients is favorable if diagnosis a...

    Authors: Wojciech Masełbas, Anna Członkowska, Tomasz Litwin and Maciej Niewada

    Citation: BMC Neurology 2019 19:278

    Content type: Research article

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