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Epilepsy

Section edited by Ravindra kumar Garg

This section is dedicated to epilepsy and seizures. Topics of interest include any condition where the main manifestations are seizures (epileptic or not), whether the issues studied pertain to diagnosis or management.

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  1. Valproate (VPA) is a commonly prescribed antiepileptic drug for patients experiencing epileptic seizures due to brain tumors. VPA increases radiation sensitivity in various tumor cells in vitro due to complex ...

    Authors: Jenny Stritzelberger, Jennifer Lainer, Stefanie Gollwitzer, Wolfgang Graf, Tina Jost, Johannes D. Lang, Tamara M. Mueller, Stefan Schwab, Rainer Fietkau, Hajo M. Hamer and Luitpold Distel

    Citation: BMC Neurology 2020 20:390

    Content type: Research article

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  2. Dynamic-related protein 1 (Drp1) is a key protein involved in the regulation of mitochondrial fission, and it could affect the dynamic balance of mitochondria and appears to be protective against neuronal inju...

    Authors: Zhong Luo, Jing Wang, Shirong Tang, Yongsu Zheng, Xuejiao Zhou, Fei Tian and Zucai Xu

    Citation: BMC Neurology 2020 20:353

    Content type: Research article

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  3. Reversible posterior leukoencephalopathy syndrome (RPLS) is a rare and heterogeneous clinico-neuroradiological syndrome characterized by headache, altered mental status, seizures, and visual disturbances. Hype...

    Authors: Kuan-Ying Li, Ching-Fang Chien, Chin-Ling Tsai, Huang-Chi Chen, Meng-Ni Wu, Chiou-Lian Lai and Li-Min Liou

    Citation: BMC Neurology 2020 20:349

    Content type: Case report

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  4. N-methyl-D-aspartate receptor (NMDAR) and leucine-rich glioma-inactivated 1 (LGI1) antibodies define the most prevalently recognized autoimmune encephalitis syndromes, while the simultaneous occurrence of both...

    Authors: Tuo Ji, Zhi Huang, Yajun Lian, Chengze Wang, Qiaoman Zhang and Jinghong Li

    Citation: BMC Neurology 2020 20:336

    Content type: Case report

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  5. Increasing evidence supports the role of soluble inflammatory mediators in the pathogenesis of refractory temporal lobe epilepsy (TLE). Hippocampal sclerosis (HS) is a well-described pathohistological abnormal...

    Authors: Pabitra Basnyat, Marko Pesu, Mikael Söderqvist, Anna Grönholm, Suvi Liimatainen, Maria Peltola, Jani Raitanen and Jukka Peltola

    Citation: BMC Neurology 2020 20:241

    Content type: Research article

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  6. Mesial temporal lobe epilepsy (MTLE) is the most common form of focal epilepsy, which is frequently characterized by hippocampal sclerosis (HS). Accumulating studies have suggested widespread cortico-cortical ...

    Authors: Dongyan Wu, Feiyan Chang, Dantao Peng, Sheng Xie, Xiaoxuan Li and Wenjing Zheng

    Citation: BMC Neurology 2020 20:235

    Content type: Research article

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  7. Interictal epileptiform discharges (IEDs) have been proven to impair cognitive function. However, it is not clear whether IEDs disrupt academic performance in children with idiopathic epilepsy, and the contrib...

    Authors: Dazhi Cheng, Xiuxian Yan, Keming Xu, Xinlin Zhou and Qian Chen

    Citation: BMC Neurology 2020 20:233

    Content type: Research article

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  9. Vagal nerve stimulation (VNS) can be an effective therapy for patients with epilepsy refractory to anti-epileptic drugs or intracranial surgery. While generally well tolerated, it has been associated with lary...

    Authors: James B. Nichols, Abigail P. McCallum, Nicolas K. Khattar, George Z. Wei, Rakesh Gopinathannair, Haring J. W. Nauta and Joseph S. Neimat

    Citation: BMC Neurology 2020 20:144

    Content type: Case report

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  10. Executive control dysfunction is observed in a sizable number of patients with temporal lobe epilepsy (TLE). Neural oscillations in the theta band are increasingly recognized as having a crucial role in execut...

    Authors: Yanping Ren, Liping Pan, Xueyun Du, Yuying Hou, Xun Li and Yijun Song

    Citation: BMC Neurology 2020 20:137

    Content type: Research article

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  13. This study aimed to explore the clinical value of long - term electroencephalogram (LTM EEG) in seizure-free individuals taking antiepileptic drugs (AEDs) for more than 2 years. We try to look for clinical fac...

    Authors: Tang Xinghua, Li Lin, Fan Qinyi, Wei Yarong, Pu Zheng and Liu Zhenguo

    Citation: BMC Neurology 2020 20:88

    Content type: Research article

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  14. Nonconvulsive status epilepticus (NCSE) is a state of ongoing seizure activity without convulsions. The heterogeneous and subtle clinical features of NCSE make diagnosis and treatment challenging. Here, we rep...

    Authors: Yi Yang, Shunyuan Zhang, Jinfeng Duan, Xianwen Zhang and Yufeng Tang

    Citation: BMC Neurology 2020 20:51

    Content type: Case report

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  15. Epilepsy and multiple sclerosis (MS) are two neurological diseases known to greatly influence a patient’s life. The primary aim of this study was to describe the prevalence of sexual dysfunction in patients wi...

    Authors: Marian Petersen, Ellids Kristensen, Laura Giraldi and Annamaria Giraldi

    Citation: BMC Neurology 2020 20:41

    Content type: Research article

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  16. In elderly patients (≥65 years of age) with epilepsy who take medications for comorbid conditions, some antiepileptic drugs (AEDs) may alter the metabolism of other treatments and increase the risk of adverse ...

    Authors: Simon Borghs, Laura Byram, Jane Chan, Peter Dedeken, John Logan, Victor Kiri, Matthias Noack-Rink, Philip N. Patsalos and Solène Thieffry

    Citation: BMC Neurology 2020 20:7

    Content type: Research article

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  19. Status epilepticus (SE) is an emergency neurological disorder that affects quality of life and is associated with high mortality risk. Three scores have been developed to predict the risk of in-hospital death, bu...

    Authors: Prapassara Sirikarn, Porjai Pattanittum and Somsak Tiamkao

    Citation: BMC Neurology 2019 19:307

    Content type: Research article

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  20. Visual field defects caused by injury to Meyer’s loop (ML) are common in patients undergoing anterior temporal lobectomy during epilepsy surgery. Evaluation of the anatomical shapes of the curving, fanning and...

    Authors: Yong-Zhi Shan, Zhen-Ming Wang, Xiao-Tong Fan, Hua-Qiang Zhang, Lian-Kun Ren, Peng-Hu Wei and Guo-Guang Zhao

    Citation: BMC Neurology 2019 19:302

    Content type: Research article

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  21. Antiepileptic drug (AED) induced dyskinesia is an unusual manifestation in the medical field. In the previous case reports describing first generation-AED related involuntary movements, the authors suggested t...

    Authors: Soo Hwan Yim, Yun Ho Choi, Kyoung Heo and Kyoo ho Cho

    Citation: BMC Neurology 2019 19:292

    Content type: Case report

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  22. In this paper, seizure types, and epilepsy syndromes are elucidated as per ILAE (2010) classification. A brief outline of the antiepileptic drug regimens used and the outcome of seizure control in a two -year ...

    Authors: Inaam N. Mohamed, Maha A. Elseed, Somia Mohamed, Ali Alsir, Emtinan K. Hamid, Ilham M. Omer, Sara M. Elsadig, Yasmin M. Gerais, Abdelgadir H. Osman, Aisha M. Bakhiet and Ahlam A. Hamed

    Citation: BMC Neurology 2019 19:290

    Content type: Research article

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  23. Many patients with chronic illness have sexual dysfunction that may be related to the condition itself, drug side effects, emotional sequel, or a combination of those factors. Patients with epilepsy are no exc...

    Authors: Alem K. Ejigu, Kelemwa H. Zewlde, Niguse Y. Muluneh, Zehara R. Seraj, Mahlet W. GebreLibanos and Yodit H. Bezabih

    Citation: BMC Neurology 2019 19:255

    Content type: Research article

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  24. We encountered two unrelated individuals suffering from neurological disorders, including epilepsy and scoliosis.

    Authors: Kouhei Den, Yosuke Kudo, Mitsuhiro Kato, Kosuke Watanabe, Hiroshi Doi, Fumiaki Tanaka, Hirokazu Oguni, Satoko Miyatake, Takeshi Mizuguchi, Atsushi Takata, Noriko Miyake, Satomi Mitsuhashi and Naomichi Matsumoto

    Citation: BMC Neurology 2019 19:253

    Content type: Case report

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  25. Nowadays, few surgery analysis has been reported in cases of epilepsy after viral encephalitis(VE). Herein, this study was to evaluate the efficacy of surgery and capability of stereoelectroencephalography (SE...

    Authors: Yi-Ou Liu, Wen-Jing Zhou, Bo Hong, Tong Zhao and Yue-feng Wang

    Citation: BMC Neurology 2019 19:165

    Content type: Research article

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  26. Epilepsy is a common neurological disease with substantial impact on the subject and their caretakers. This exploratory study identified barriers to care for persons living with epilepsy (PLWE) to develop a cu...

    Authors: Mark Kaddumukasa, Haddy Nalubwama, Martin N. Kaddumukasa, Samden Lhatoo, Nelson Sewankambo, Elly Katabira, Martha Sajatovic and Carol Blixen

    Citation: BMC Neurology 2019 19:161

    Content type: Research article

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  27. Epigenetics underlying refractory epilepsy is poorly understood. DNA methylation may affect gene expression in epilepsy patients without affecting DNA sequences. Herein, we investigated the association between...

    Authors: Yudan Lv, Xiangyu Zheng, Mingchao Shi, Zan Wang and Li Cui

    Citation: BMC Neurology 2019 19:114

    Content type: Research article

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  28. Gall bladder cancer (GBC) is associated with abdominal pain, lump, nausea, vomiting, and jaundice due to either gall bladder mass or the involved adjacent peritoneal structures. Gall bladder cancer presenting ...

    Authors: Shweta Pandey, Ravindra Kumar Garg, Hardeep Singh Malhotra, Ravi Uniyal and Neeraj Kumar

    Citation: BMC Neurology 2019 19:95

    Content type: Case report

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  29. Albeit the few resting-state fMRI neuroimaging studies in frontal lobe epilepsy (FLE) patients, these studies focused on functional connectivity. The aim of this current study was to examine the effective conn...

    Authors: Benjamin Klugah-Brown, Cheng Luo, Rui Peng, Hui He, Jianfu Li, Li Dong and Dezhong Yao

    Citation: BMC Neurology 2019 19:70

    Content type: Research article

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  31. Individuals with epilepsy who cannot be adequately controlled with anti-epileptic drugs, refractory epilepsy, may be suitable for surgical treatment following detailed assessment. This is a complex process and...

    Authors: Virginia Mumford, Frances Rapport, Patti Shih, Rebecca Mitchell, Andrew Bleasel, Armin Nikpour, Geoffrey Herkes, Amy MacRae, Melissa Bartley, Sanjyot Vagholkar and Jeffrey Braithwaite

    Citation: BMC Neurology 2019 19:29

    Content type: Research article

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  32. Epilepsy is one of the most common chronic disabling neurologic diseases. The purpose of our study was to investigate whether there is an association between t-PA (tissue plasminogen activator, rs2020918 and rs46...

    Authors: Wenxiu Han, Pei Jiang, Yujin Guo, Pengfei Xu, Ruili Dang, Gongying Li, Xin He, Dehua Liao and Genquan Yan

    Citation: BMC Neurology 2019 19:13

    Content type: Research article

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  33. Living with a chronic condition such as epilepsy can have a debilitating effect on the individual and their carers. Managing epilepsy among people with learning disabilities may present a challenge because of ...

    Authors: Jerry Paul K. Ninnoni

    Citation: BMC Neurology 2019 19:12

    Content type: Research article

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  34. Recurrent seizure risks in HIV-positive people with new-onset seizure are largely unknown, making it challenging to offer optimal recommendations regarding antiepileptic drug (AED) initiation. Existing outcome...

    Authors: Melissa A. Elafros, Brent A. Johnson, Omar K. Siddiqi, Jason F. Okulicz, Izukanji Sikazwe, Christopher M. Bositis, Michael J. Potchen, Igor J. Koralnik, William H. Theodore, Lisa Kalungwana and Gretchen L. Birbeck

    Citation: BMC Neurology 2018 18:201

    Content type: Research article

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  35. Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic condition which comprises various neurological symptoms. This syndrome could be complicated by intracranial hemorrhage including subarachnoid...

    Authors: Dan Hu, Jing Xiong, Yunfei Zha and Zhaohui Zhang

    Citation: BMC Neurology 2018 18:182

    Content type: Case report

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  36. Posterior reversible encephalopathy syndrome (PRES) is a reversible clinical and neurological entity. There are varieties of comorbid conditions which are associated with PRES. Chronic obstructive pulmonary di...

    Authors: Sushil Khanal and Subhash Prasad Acharya

    Citation: BMC Neurology 2018 18:180

    Content type: Case report

    Published on:

  37. Crohn’s disease (CD) is associated with a variety of extra-intestinal manifestations. Most commonly these involve the eye, skin, joints, coagulation system and liver. Cerebral manifestations of CD have been re...

    Authors: Konrad Whittaker, Konstanze Guggenberger, Nils Venhoff, Soroush Doostkam, Hans-Eckart Schaefer and Brita Fritsch

    Citation: BMC Neurology 2018 18:161

    Content type: Case report

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  38. Little is known of how accurately a first-time seizure witness can provide reliable details of a semiology. Our goal was to determine how accurately first-time seizure witnesses could identify key elements of ...

    Authors: Taim A. Muayqil, Mohammed H. Alanazy, Hassan M. Almalak, Hussain Khaled Alsalman, Faroq Walid Abdulfattah, Abdullah Ibrahim Aldraihem, Fawaz Al-hussain and Bandar N. Aljafen

    Citation: BMC Neurology 2018 18:135

    Content type: Research article

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  39. Seizures arising from the precuneus are rare, and few studies have aimed at characterizing the clinical presentation of such seizures within the anatomic context of the frontoparietal circuits. We aimed to cha...

    Authors: Yanfeng Yang, Haixiang Wang, Wenjing Zhou, Tianyi Qian, Wei Sun and Guoguang Zhao

    Citation: BMC Neurology 2018 18:110

    Content type: Research article

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  40. Epileptic seizures can lead to cardiac arrhythmias. The arrhythmias may be in the form of tachycardia, bradycardia or asystole. Ictal bradycardia and asystole can lead to sudden unexpected death.

    Authors: Nirmeen Kishk, Amani Nawito, Ahmed El-Damaty and Amany Ragab

    Citation: BMC Neurology 2018 18:100

    Content type: Case report

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  41. Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs),...

    Authors: Mumin Alper Erdogan, Dimas Yusuf, Joanna Christy, Volkan Solmaz, Arife Erdogan, Emin Taskiran and Oytun Erbas

    Citation: BMC Neurology 2018 18:81

    Content type: Research article

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  43. The general principles in the administration of anesthetic drugs entail not only the suppression of seizure activity but also the achievement of electroencephalography burst suppression (BS). However, previous...

    Authors: Kanitpong Phabphal, Suparat Chisurajinda, Thapanee Somboon, Kanjana Unwongse and Alan Geater

    Citation: BMC Neurology 2018 18:46

    Content type: Research article

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  44. The aim of this study was to evaluate whether the glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null alleles may contribute to carbamazepine-induced hepatotoxicity.

    Authors: Chahra Chbili, Anis Hassine, Neila Fathallah, Manel Nouira, Salma Naija, Sofiene Ben Ammou and Saad Saguem

    Citation: BMC Neurology 2018 18:24

    Content type: Research article

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  45. Generalized tonic-clonic seizures (GTCS) frequently lead to emergency inpatient referrals. Laboratory blood values are routinely performed on admission to detect underlying causes and metabolic or cardiac comp...

    Authors: Robert D. Nass, Sina Meiling, René P. Andrié, Christian E. Elger and Rainer Surges

    Citation: BMC Neurology 2017 17:187

    Content type: Research article

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  46. The insular cortex is not routinely removed in modified functional hemispherectomy due to the risk of injury to the main arteries and to deep structures. Our study evaluates the safety and usefulness of applyi...

    Authors: Gun-Ha Kim, Joo Hee Seo, James E. Baumgartner, Fatima Ajmal and Ki Hyeong Lee

    Citation: BMC Neurology 2017 17:162

    Content type: Research article

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  47. Epilepsy is a serious and costly long-term condition that negatively affects quality of life, especially if seizures persist on medication. Studies show that people with epilepsy (PWE) want to learn more about...

    Authors: Amelia Smith, Alison McKinlay, Gabriella Wojewodka and Leone Ridsdale

    Citation: BMC Neurology 2017 17:114

    Content type: Research article

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  48. Vagal nerve stimulation (VNS) for refractory epilepsy is well established. Trigeminal neuralgia itself is a common disease in adults, and thus, late-onset pain in the trigeminal region under VNS, which is extr...

    Authors: Gabriela Timarova and Andrej Šteňo

    Citation: BMC Neurology 2017 17:113

    Content type: Case report

    Published on:

  49. Some antiepileptic drugs (AEDs) induce expression of hepatic enzymes. This can contribute to comorbidities via interference with metabolic pathways and concomitant drug metabolization, thereby increasing the l...

    Authors: Simon Borghs, Solène Thieffry, Matthias Noack-Rink, Peter Dedeken, Lai San Hong, Laura Byram, John Logan, Jane Chan and Victor Kiri

    Citation: BMC Neurology 2017 17:59

    Content type: Research article

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  50. Mindfulness based interventions (MBIs) are increasingly used to help patients cope with physical and mental long-term conditions (LTCs). Epilepsy is associated with a range of mental and physical comorbidities...

    Authors: Karen Wood, Maggie Lawrence, Bhautesh Jani, Robert Simpson and Stewart W. Mercer

    Citation: BMC Neurology 2017 17:52

    Content type: Research article

    Published on:

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