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Cerebrovascular disease and stroke

Section edited by Szatmari Szabolcs

This section is dedicated to covering all aspects of stroke and cerebrovascular diseases. Topics of interest include, but are not limited to, ischemic stroke, spontaneous intracranial bleeding, sinus thrombosis, carotid or vertebral artery disease, cerebrovascular physiology, and neuroimaging related to cerebrovascular diseases.

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  1. Benign gynecologic tumor, such as uterine adenomyosis, has been suggested to develop hypercoagulability. Although some cases of cerebral infarction associated with adenomyosis have been reported, the mechanism...

    Authors: Yasuhiro Aso, Ryo Chikazawa, Yuki Kimura, Noriyuki Kimura and Etsuro Matsubara

    Citation: BMC Neurology 2018 18:119

    Content type: Case report

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  2. Insulin-like growth factor I (IGF-I) has neuroprotective effects in experimental ischemic stroke (IS). However, in patients who have suffered IS, various associations between the levels of serum IGF-I (s-IGF-I...

    Authors: N. David Åberg, Daniel Åberg, Katarina Jood, Michael Nilsson, Christian Blomstrand, H. Georg Kuhn, Johan Svensson, Christina Jern and Jörgen Isgaard

    Citation: BMC Neurology 2018 18:106

    Content type: Research article

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  3. After stroke, spasticity of the rectus femoris (RF) and triceps surae (TS) muscles frequently alters the gait pattern. Knee flexion and ankle dorsiflexion in swing are often reduced, respectively called Stiff ...

    Authors: Anthony Supiot, Maxime Geiger, Djamel Bensmail, Phillippe Aegerter, Didier Pradon and Nicolas Roche

    Citation: BMC Neurology 2018 18:104

    Content type: Study protocol

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  4. Brief measures of health-related quality of life (HRQOL) that assess both patient-reported functioning and well-being after stroke are scarce. The objective of this study was to examine reliability and validit...

    Authors: Guri Heiberg, Synne Garder Pedersen, Oddgeir Friborg, Jørgen Feldbæk Nielsen, Henriette Stabel Holm, Nicole Steinbüchel von, Cathrine Arntzen and Audny Anke

    Citation: BMC Neurology 2018 18:98

    Content type: Research article

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  5. Young ischemic stroke patients are common while classification and analysis based upon imaging characteristics are rarely reported. We intend to compare the clinical and MRI characteristics of cerebral stroke ...

    Authors: Zhang-Ning Zhao, Xiao-Lin Li, Jin-Zhi Liu, Zhi-Ming Jiang and Ai-Hua Wang

    Citation: BMC Neurology 2018 18:87

    Content type: Research article

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  6. The plaques at the dorsal or lateral wall of basilar artery (BA) are associated with pontine infarcts. We sought to explore the correlations between vertebrobasilar artery geometry and BA plaque locations.

    Authors: Jin Yu, Shu Zhang, Ming-Li Li, Yi Ma, Yu-Ru Dong, Min Lou, Feng Feng, Shan Gao, Shi-Wen Wu and Wei-Hai Xu

    Citation: BMC Neurology 2018 18:83

    Content type: Research article

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  7. There is uncertainty regarding the effect of anemia and red blood cell transfusion on functional outcome following acute ischemic stroke. We studied the relationship of hemoglobin parameters and red cell trans...

    Authors: Kartavya Sharma, Daniel J. Johnson, Brenda Johnson, Steven M. Frank and Robert D. Stevens

    Citation: BMC Neurology 2018 18:78

    Content type: Research article

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  8. Cervical artery dissection is one of the most important causes of ischemic stroke in young age patients. However, multiple cervical artery dissection simultaneously involving the anterior and posterior circula...

    Authors: Sung eun Chung, Tae Hwan Yoon, Kyung Mi Lee, Hyug-Gi Kim and Bum Joon Kim

    Citation: BMC Neurology 2018 18:74

    Content type: Case report

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  9. Epilepsy is a major complication of stroke. We aimed to establish whether there is an association between intravenous thrombolysis, intra-arterial thrombolysis and post stroke seizure (PSS) development. Improv...

    Authors: Jillian Naylor, Arthur Thevathasan, Leonid Churilov, Ruibing Guo, Yunyun Xiong, Miriam Koome, Ziyi Chen, Ziyuan Chen, Xinfeng Liu, Patrick Kwan and Bruce C. V. Campbell

    Citation: BMC Neurology 2018 18:61

    Content type: Research article

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  10. Endovascular techniques have proven beneficial in the treatment of aneurysmal subarachnoid hemorrhage (aSAH), but with high risk of arterial clotting, emboli and dissection. Platelet activation and alterations...

    Authors: Pauline Perez, Anne-Claire Lukaszewicz, Stephanie Lenck, Rémy Nizard, Ludovic Drouet and Didier Payen

    Citation: BMC Neurology 2018 18:57

    Content type: Research article

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  11. It is usually difficult to identify stroke pathogenesis for single lenticulostriate infarction with nonstenotic middle cerebral artery (MCA). Our aim is to differentiate the two pathogeneses, non-branch athero...

    Authors: Li-Li Sun, Zhong-Hao Li, Wen-Xiong Tang, Lei Liu, Fei-Yan Chang, Xue-Bin Zhang, Wei-Jie Ye, Shuo Lu, Zun-Jing Liu and Xian-Jin Zhu

    Citation: BMC Neurology 2018 18:51

    Content type: Research article

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  12. Caregiver burden may be either a predictor or an outcome of caregiver quality of life (QoL). Patient or caregiver factors that directly affect caregiver QoL, predictors that are simultaneously shared with care...

    Authors: Yu-Hsia Tsai, Meei-Fang Lou, Tsui-Hsia Feng, Tsung-Lan Chu, Ying-Jen Chen and Hsueh-Erh Liu

    Citation: BMC Neurology 2018 18:50

    Content type: Research article

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  13. Vertebrobasilar dolichoectasia (VBD) is a clinical entity associated with ischemic stroke, compression of cranial nerves or brainstem, and hydrocephalus. There have been relatively few studies following the pr...

    Authors: Dao Pei Zhang, Yan Fang Peng, Qian Kun Ma, Min Zhao, Huai Liang Zhang and Suo Yin

    Citation: BMC Neurology 2018 18:45

    Content type: Case report

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  14. Idiopathic basal ganglia calcification (IBGC) is a rare neurodegenerative disorder characterized by symmetric intracranial calcium deposition. We report a patient with IBGC associated with cerebral infarction ...

    Authors: Takuma Nishimoto, Fumiaki Oka, Hideyuki Ishihara, Mizuya Shinoyama and Michiyasu Suzuki

    Citation: BMC Neurology 2018 18:42

    Content type: Case report

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  15. Stroke survivors are more physically inactive than even the most sedentary older adults, and low activity is associated with increased risk of recurrent stroke, medical complications, and mortality. We hypothe...

    Authors: Henry Wright, Tamara Wright, Ryan T. Pohlig, Scott E. Kasner, Jonathan Raser-Schramm and Darcy Reisman

    Citation: BMC Neurology 2018 18:39

    Content type: Study protocol

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  16. Transient global amnesia is reported to be caused by cerebral venous congestion. Internal jugular venous flow reversal in particular with the Valsalva maneuver leads to cerebral venous congestion. In addition,...

    Authors: Yuta Maetani, Masahiro Nakamori, Tomoaki Watanabe, Hayato Matsushima, Eiji Imamura and Shinichi Wakabayashi

    Citation: BMC Neurology 2018 18:36

    Content type: Case report

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  17. Intravenous tissue plasminogen activator (IV tPA) after acute ischemic stroke carries the risk of symptomatic intracerebral hemorrhage (sICH). Cerebral microbleeds (CMBs) may indicate increased risk of hemorrh...

    Authors: Martin A. Chacon-Portillo, Rafael H. Llinas and Elisabeth B. Marsh

    Citation: BMC Neurology 2018 18:33

    Content type: Research article

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  18. There have been found apoptotic changes in brain tissue samples from humans after cerebral ischemia. Caspase-cleaved cytokeratin (CCCK)-18 could appears in blood during apoptosis. High circulating levels of CC...

    Authors: Leonardo Lorente, María M. Martín, Antonia Pérez-Cejas, Luis Ramos, Mónica Argueso, Jordi Solé-Violán, Juan J. Cáceres, Alejandro Jiménez and Victor García-Marín

    Citation: BMC Neurology 2018 18:32

    Content type: Research article

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  19. Intracerebral hemorrhage is a devastating disease with no specific treatment modalities. A significant proportion of patients with intracerebral hemorrhage are transferred to large stroke treatment centers, su...

    Authors: Farhaan S. Vahidy, Ellie G. Meyer, Arvind B. Bambhroliya, Jennifer R. Meeks, Charles E. Begley, Tzu-Ching Wu, Jon E. Tyson, Charles C. Miller, Ritvij Bowry, Wamda O. Ahmed, Gretchel A. Gealogo, Louise D. McCullough, Steven Warach and Sean I. Savitz

    Citation: BMC Neurology 2018 18:31

    Content type: Study protocol

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  20. A significant proportion of patients with mild ischemic stroke become disabled despite receiving intravenous thrombolytic therapy. The purpose of this study was to assess the clinical and radiological factors ...

    Authors: Dae-Hyun Kim, Deok-Soo Lee, Hyun-Wook Nah and Jae-Kwan Cha

    Citation: BMC Neurology 2018 18:30

    Content type: Research article

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  21. Prognostic models have been increasingly developed to predict complete recovery in ischemic stroke. However, questions arise about the performance characteristics of these models. The aim of this study was to ...

    Authors: Nampet Jampathong, Malinee Laopaiboon, Siwanon Rattanakanokchai and Porjai Pattanittum

    Citation: BMC Neurology 2018 18:26

    Content type: Research article

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  22. Chronic kidney disease increases stroke incidence and severity but the mechanisms behind this cerebro-renal interaction are mostly unexplored. Since both vascular beds share similar features, microvascular dys...

    Authors: Pedro Castro, Elsa Azevedo, Isabel Rocha, Farzaneh Sorond and Jorge M. Serrador

    Citation: BMC Neurology 2018 18:21

    Content type: Research article

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  23. Clinical scales to detect large vessel occlusion (LVO) may help to determine the optimal transport destination for patients with suspected acute ischemic stroke (AIS). The clinical benefit associated with impr...

    Authors: Ludwig Schlemm and Eckhard Schlemm

    Citation: BMC Neurology 2018 18:16

    Content type: Research article

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  24. The level of physical activity undertaken by stroke survivors living in the community is generally low. The main objectives of the IMPACT trial are to determine, in individuals undergoing rehabilitation after str...

    Authors: Sandra G. Brauer, Suzanne S. Kuys, Jennifer D. Paratz and Louise Ada

    Citation: BMC Neurology 2018 18:13

    Content type: Study protocol

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  25. Data on the association between socioeconomic status and post-stroke functional outcome in developing countries is lacking. We aimed to evaluate the association in stroke survivors in deprived rural Southern C...

    Authors: Fubing Ouyang, Ying Wang, Weixian Huang, Yicong Chen, Yuhui Zhao, Ge Dang, Chunbo Zhang, Yang Lin and Jinsheng Zeng

    Citation: BMC Neurology 2018 18:12

    Content type: Research article

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  26. Following the success of recent endovascular trials, endovascular therapy has emerged as an exciting addition to the arsenal of clinical management of patients with acute ischemic stroke (AIS). In this paper, ...

    Authors: Sonu Bhaskar, Peter Stanwell, Dennis Cordato, John Attia and Christopher Levi

    Citation: BMC Neurology 2018 18:8

    Content type: Review

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  27. Cervicocephalic artery dissection (CAD) is an important etiology of stroke in the youth. Findings from recent studies suggest it a “group of disease entities” with different underlying etiologies, presentation...

    Authors: Zhu Zhu, Yuyuan Xu, Yilong Wang, Zhenhua Zhou, Xiang Han, Aihua Liu, Jing Peng, Yi Xu and Luyao Wang

    Citation: BMC Neurology 2018 18:6

    Content type: Study protocol

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  28. Repetitive sensory stimulation (RSS) adapts the timing of stimulation protocols used in cellular studies to induce synaptic plasticity. In healthy subjects, RSS leads to widespread sensorimotor cortical reorga...

    Authors: Jan C. Kattenstroth, Tobias Kalisch, Matthias Sczesny-Kaiser, Wolfgang Greulich, Martin Tegenthoff and Hubert R. Dinse

    Citation: BMC Neurology 2018 18:2

    Content type: Research article

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  29. Cortical vein thrombosis (CVT) receives little attention in adult patients with cerebral venous sinus thrombosis (CVST). This study aimed to investigate the clinical and radiological features of adult CVST pat...

    Authors: Jiahui Liang, Hongbing Chen, Zhuhao Li, Shaofu He, Boning Luo, Shujin Tang, Wenjin Shang and Jinsheng Zeng

    Citation: BMC Neurology 2017 17:219

    Content type: Research article

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  30. Growing evidence indicates that elevated body temperature after stroke is associated with unfavorable outcome. The aim of the current study was to investigate which factors predict temperature elevation within...

    Authors: Rebecca Ruborg, Karin Gunnarsson and Jakob O. Ström

    Citation: BMC Neurology 2017 17:218

    Content type: Research article

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  31. Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome, is the most common phenotype of mitochondrial disease. It often develops in childhood or adolescence, usually ...

    Authors: Satomi Mezuki, Kenji Fukuda, Tomonaga Matsushita, Yoshihisa Fukushima, Ryu Matsuo, Yu-ichi Goto, Takehiro Yasukawa, Takeshi Uchiumi, Dongchon Kang, Takanari Kitazono and Tetsuro Ago

    Citation: BMC Neurology 2017 17:217

    Content type: Case report

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  32. Secondary pallidonigral transneuronal degeneration after a remote primary cerebral infarct can mimic recurrent stroke at clinical presentation. We describe a patient with secondary pallidonigral degeneration f...

    Authors: Ruei-Je Tsai, Li-Chun Hsieh, Sho-Jen Cheng and Cheng-Yu Chen

    Citation: BMC Neurology 2017 17:215

    Content type: Case report

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  33. Thalamic hemorrhages cause motor paralysis, sensory impairment, and cognitive dysfunctions, all of which may significantly affect walking independence. We examined the factors related to independent walking in...

    Authors: Shigenori Hiraoka, Shinichiro Maeshima, Hideto Okazaki, Hirokazu Hori, Shinichiro Tanaka, Sayaka Okamoto, Reisuke Funahashi, Kei Yagihashi, Ikuko Fuse, Naoki Asano and Shigeru Sonoda

    Citation: BMC Neurology 2017 17:211

    Content type: Research article

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  34. Atrial fibrillation (AF) is reported to be a less frequent cause of ischemic stroke in China than in Europe and North America, but it is not clear whether this is due to underestimation. Our aim was to define ...

    Authors: Xiaomeng Yang, Shuya Li, Xingquan Zhao, Liping Liu, Yong Jiang, Zixiao Li, Yilong Wang and Yongjun Wang

    Citation: BMC Neurology 2017 17:207

    Content type: Research article

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  35. Clinical trials are the hallmark of evidence-based medicine, but recruitment is often challenging, especially in stroke trials investigating patients not being able to give informed consent. In some nations, e...

    Authors: Benjamin Hotter, Lena Ulm, Sarah Hoffmann, Mira Katan, Joan Montaner, Alejandro Bustamante and Andreas Meisel

    Citation: BMC Neurology 2017 17:206

    Content type: Research article

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  36. Evaluation of secondary stroke prevention in low and middle-income countries remains limited. This study assessed the prescription of secondary preventive drugs among ischemic stroke patients upon hospital dis...

    Authors: Wen Yea Hwong, Zariah Abdul Aziz, Norsima Nazifah Sidek, Michiel L. Bots, Sharmini Selvarajah, L. Jaap Kappelle, Sheamini Sivasampu and Ilonca Vaartjes

    Citation: BMC Neurology 2017 17:203

    Content type: Research article

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  37. Post-stroke depression (PSD) seriously affects the rehabilitation of nerve function and quality of life. However, the pathogenesis of PSD is still not clear. This study aimed to investigate the demographic, cl...

    Authors: Guilin Meng, Xiaoye Ma, Lei Li, Yan Tan, Xiaohui Liu, Xueyuan Liu and Yanxin Zhao

    Citation: BMC Neurology 2017 17:199

    Content type: Research article

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  38. The neuroprotective effects of neuroserpin (NSP) have been well documented in both patients and animal models with cerebral ischemia; however, have never been investigated in hemorrhagic stroke. The aim of thi...

    Authors: Wei Li, Tetsuya Asakawa, Sha Han, Baoguo Xiao, Hiroki Namba, Chuanzhen Lu, Qiang Dong and Liang Wang

    Citation: BMC Neurology 2017 17:196

    Content type: Research article

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  39. Supernumerary phantom limb (SPL) is a rare neurologic phenomenon, in which a patient misperceives an extra limb in addition to the original set of limbs. We report a case of SPL in a patient with a right basal...

    Authors: Hang-Rai Kim, Jee-young Han, Young Ho Park, Beom Joon Kim, Wookjin Yang and SangYun Kim

    Citation: BMC Neurology 2017 17:180

    Content type: Case report

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  40. Stroke is a leading cause of death and disability, and despite intensive research, few treatment options exist. However, a recent breakthrough in cell therapy is expected to reverse the neurological sequelae o...

    Authors: Hideo Shichinohe, Masahito Kawabori, Hiroaki Iijima, Tuyoshi Teramoto, Takeo Abumiya, Naoki Nakayama, Ken Kazumata, Shunsuke Terasaka, Teruyo Arato and Kiyohiro Houkin

    Citation: BMC Neurology 2017 17:179

    Content type: Study protocol

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  41. We aimed to develop a tool, the hemorrhagic transformation (HT) index (HTI), to predict any HT within 14 days after middle cerebral artery (MCA) stroke onset regardless of the intravenous recombinant tissue pl...

    Authors: Mikhail N. Kalinin, Dina R. Khasanova and Murat M. Ibatullin

    Citation: BMC Neurology 2017 17:177

    Content type: Research article

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  42. While neurogranin has no value as plasma biomarker for Alzheimer’s disease, it may be a potential blood biomarker for traumatic brain injury. This evokes the question whether there are changes in neurogranin l...

    Authors: Ann De Vos, Maria Bjerke, Raf Brouns, Naomi De Roeck, Dirk Jacobs, Lien Van den Abbeele, Kaat Guldolf, Henrik Zetterberg, Kaj Blennow, Sebastiaan Engelborghs and Eugeen Vanmechelen

    Citation: BMC Neurology 2017 17:170

    Content type: Research article

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  43. In order to evaluate the impact of cilostazol on endothelial function, we compared the changes of flow-mediated dilation (FMD) between aspirin and cilostazol groups in patients with acute cerebral ischemia.

    Authors: Seong-Joon Lee, Jin Soo Lee, Mun Hee Choi, Sung Eun Lee, Dong Hoon Shin and Ji Man Hong

    Citation: BMC Neurology 2017 17:169

    Content type: Research article

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  44. Whether there are differences in pathogenesis among different types and subtypes of cerebral watershed infarction (WSI) is controversial since they have been combined into a single group in most previous studies.

    Authors: Yue Li, Man Li, Xiaoyu Zhang, Shuna Yang, Huimin Fan, Wei Qin, Lei Yang, Junliang Yuan and Wenli Hu

    Citation: BMC Neurology 2017 17:166

    Content type: Research article

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  45. Non-traumatic, spontaneous subarachnoid hemorrhage occurs in approximately 85% of cases where there is a ruptured saccular aneurysm. An additional 10% of cases arise from non-aneurysmal peri-mesencephalic hemo...

    Authors: Anna Misyail Abdul Rashid and Mohamad Syafeeq Faeez Md Noh

    Citation: BMC Neurology 2017 17:165

    Content type: Case report

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  46. Standard echocardiography (SE) is an essential part of the routine diagnostic work-up after ischemic stroke (IS) and also serves for research purposes. However, access to SE is often limited. We aimed to asses...

    Authors: Peter Kraft, Anna Fleischer, Silke Wiedmann, Viktoria Rücker, Daniel Mackenrodt, Caroline Morbach, Uwe Malzahn, Christoph Kleinschnitz, Stefan Störk and Peter U. Heuschmann

    Citation: BMC Neurology 2017 17:159

    Content type: Research article

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