From: Predictors of very early stroke recurrence in the POINT trial population
Predictor | ER (−) (N = 4700) | ER (+) (N = 181) | P |
---|---|---|---|
Demographics | |||
Age (median, yrs) [IQR] | 65 [55,74] | 64 [57,76] | 0.19a |
Gender (% male) | 55.0 | 55.8 | 0.89 b |
Race (% white) | 73.1 | 65.2 | 0.11c |
Ethnicity (% Hispanic or Latino) | 8.0 | 6.1 | 0.62b |
Medical history | |||
Hypertension (%) | 68.8 | 76.2 | 0.076c |
Diabetes Mellitus (%) | 27.3 | 48.4 | 0.27c |
Smoking status (% present smoker) | 20.5 | 24.3 | 0.40c |
Ischemic heart disease (%) | 10.3 | 7.7 | 0.23c |
Carotid disease (%) | 4.2 | 5.5 | 0.44c |
Congestive heart failure (%) | 2.6 | 1.1 | 0.49c |
Valvular heart disease (%) | 1.7 | 2.2 | 0.71c |
Atrial fibrillation (%) | 1.0 | 1.1 | 0.83c |
Peptic ulcer disease (%) | 1.0 | 0.6 | 0.080c |
Medications at baseline | |||
Aspirin (%) | 57.6 | 59.7 | 0.63b |
Statins (%) | 39.0 | 32.0 | 0.13c |
Other lipid lowering agents (%) | 4.8 | 2.8 | 0.28c |
Clopidogrel (%) | 1.9 | 1.1 | 0.78c |
Dipyridamole (%) | 0.4 | 0.0 | 1c |
Ticlopidine (%) | 0.0 | 0.0 | 1c |
Anticoagulantsc (%) | 3.3 | 3.3 | 1c |
Other interacting agents (%) | 21.1 | 19.3 | 0.67c |
Clinical features at presentation | |||
Cohort (minor stroke vs. TIA) (% minor stroke) | 56.3 | 70.7 | < 0.001b |
Glucose (mg/dL) (median) [IQR] | 110 [97, 138] | 121 [105, 155] | < 0.001a |
WBC (103/uL) (median) [IQR] | 7.4 [6.1, 8.9] | 7.3 [5.9, 9.3] | 0.96a |
RBC (106/uL) (median) [IQR] | 4.7 [4.3, 5.0] | 4.7 [4.3, 5.1] | 0.42a |
Hgb (mg/dL) (median) [IQR] | 14.1 [13.1, 15.1] | 14.2 [13.1, 15.1] | 0.75a |
Hematocrit (%) (median) [IQR] | 42.0 [39, 45] | 42.3 [39, 45] | 0.64a |
Platelets (103/uL) (median) [IQR] | 227 [190, 270] | 233 [190, 266] | 0.90a |
Systolic BP (mmHg) (median) [IQR] | 158 [143, 179] | 168 [150, 193] | < 0.001a |
Diastolic BP (mmHg) (median) [IQR] | 87 [76, 98] | 90 [80, 104] | 0.0042a |
Treatment | |||
Arrival to randomization time (min) (median), [IQR] | − 251 [− 375, − 167] | − 225 [− 384, − 176] | 0.38a |
Treatment assignment (%) | 49.7 | 61.3 | 0.0029 b |
Clinical findings | |||
Carotid imaging results (% with any stenosis > 50%) | 3.6 | 8.2 | < 0.001c |