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Table 1 Predictors of Early Recurrence (ER) in the POINT trial population - Univariate analysis

From: Predictors of very early stroke recurrence in the POINT trial population

Predictor

ER (−)

(N = 4700)

ER (+)

(N = 181)

P

Demographics

 Age (median, yrs) [IQR]

65 [55,74]

64 [57,76]

0.19a

 Gender (% male)

55.0

55.8

0.89 b

 Race (% white)

73.1

65.2

0.11c

 Ethnicity (% Hispanic or Latino)

8.0

6.1

0.62b

Medical history

 Hypertension (%)

68.8

76.2

0.076c

 Diabetes Mellitus (%)

27.3

48.4

0.27c

 Smoking status (% present smoker)

20.5

24.3

0.40c

 Ischemic heart disease (%)

10.3

7.7

0.23c

 Carotid disease (%)

4.2

5.5

0.44c

 Congestive heart failure (%)

2.6

1.1

0.49c

 Valvular heart disease (%)

1.7

2.2

0.71c

 Atrial fibrillation (%)

1.0

1.1

0.83c

 Peptic ulcer disease (%)

1.0

0.6

0.080c

Medications at baseline

 Aspirin (%)

57.6

59.7

0.63b

 Statins (%)

39.0

32.0

0.13c

 Other lipid lowering agents (%)

4.8

2.8

0.28c

 Clopidogrel (%)

1.9

1.1

0.78c

 Dipyridamole (%)

0.4

0.0

1c

 Ticlopidine (%)

0.0

0.0

1c

 Anticoagulantsc (%)

3.3

3.3

1c

 Other interacting agents (%)

21.1

19.3

0.67c

Clinical features at presentation

 Cohort (minor stroke vs. TIA) (% minor stroke)

56.3

70.7

< 0.001b

 Glucose (mg/dL) (median) [IQR]

110 [97, 138]

121 [105, 155]

< 0.001a

 WBC (103/uL) (median) [IQR]

7.4 [6.1, 8.9]

7.3 [5.9, 9.3]

0.96a

 RBC (106/uL) (median) [IQR]

4.7 [4.3, 5.0]

4.7 [4.3, 5.1]

0.42a

 Hgb (mg/dL) (median) [IQR]

14.1 [13.1, 15.1]

14.2 [13.1, 15.1]

0.75a

 Hematocrit (%) (median) [IQR]

42.0 [39, 45]

42.3 [39, 45]

0.64a

 Platelets (103/uL) (median) [IQR]

227 [190, 270]

233 [190, 266]

0.90a

 Systolic BP (mmHg) (median) [IQR]

158 [143, 179]

168 [150, 193]

< 0.001a

 Diastolic BP (mmHg) (median) [IQR]

87 [76, 98]

90 [80, 104]

0.0042a

Treatment

 Arrival to randomization time (min) (median), [IQR]

− 251 [− 375, − 167]

− 225 [− 384, − 176]

0.38a

 Treatment assignment (%)

49.7

61.3

0.0029 b

Clinical findings

 Carotid imaging results (% with any stenosis > 50%)

3.6

8.2

< 0.001c

  1. a By Wilcoxon Rank Sum test; b by Chi-squared testing with Yate’s correction; c By Fisher’s Exact test