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Table 3 Reclassification and discrimination statistics for outcomes within 90 days and 1 year by serum bilirubin

From: Serum bilirubin levels are associated with poor functional outcomes in patients with acute ischemic stroke or transient ischemic attack

  C statistic IDI Category-free NRI
Estimate (95% CI) P value Estimate (95% CI), % P value Estimate (95% CI), % P value
Outcomes at 3 months
 mRS score 2-6
  Conventional modela 0.762(0.752-0.772)   Reference   Reference  
  Conventional model+TBIL 0.763(0.753-0.773) 0.0437 2.07(1.10-3.00) <0.0001 8.56(4.33-12.80) <0.0001
  Conventional model+DBIL 0.762(0.753-0.773) 0.1089 2.12(1.20-3.10) <0.0001 8.43(4.18-12.68) 0.0001
  Conventional model+IBIL 0.763(0.753-0.773) 0.0443 1.52(0.07-2.40) 0.0004 7.17(2.94-11.41) 0.0010
 mRS score 3-6
  Conventional modela 0.780(0.768-0.792)   Reference   Reference  
  Conventional model+TBIL 0.782(0.770-0.794) 0.0252 2.44(1.10-3.70) 0.0003 10.53(5.15-15.90) 0.0001
  Conventional model+DBIL 0.782(0.770-0.794) 0.0432 4.50(2.70-6.30) <0.0001 10.56(5.18-15.95) 0.0001
  Conventional model+IBIL 0.781(0.769-0.793) 0.0431 1.18(0.20-2.10) 0.0138 8.03(2.66-13.40) 0.0037
Outcomes at 1 year
 mRS score 2-6
  Conventional modela 0.738(0.727-0.749)   Reference   Reference  
  Conventional model+TBIL 0.739(0.728-0.750) 0.0497 1.64(0.70-2.50) 0.0003 7.23(2.85-111.62) 0.0014
  Conventional model+DBIL 0.739(0.728-0.749) 0.1763 1.84(0.09-2.80) 0.0001 6.10(1.68-10.48) 0.0072
  Conventional model+IBIL 0.739(0.728-0.750) 0.0379 1.13(0.40-1.90) 0.0034 5.64(2.26-10.03) 0.0127
 mRS score 3-6
  Conventional modela 0.776(0.764-0.790)   Reference   Reference  
  Conventional model+TBIL 0.778(0.765-0.791) 0.0667 1.82(0.06-3.10) 0.0040 6.16(0.69-11.63) 0.0239
  Conventional model+DBIL 0.779(0.766-0.792) 0.0319 3.79(2.00-5.60) <0.0001 8.71(3.21-14.21) 0.0021
  Conventional model+IBIL 0.777(0.764-0.790) 0.1432 0.76(0.01-1.60) 0.0378 4.77(0.70-10.24) 0.0415
  1. Abbreviations: CI confidence interval, DBIL direct bilirubin, IBIL indirect bilirubin, IDI integrated discrimination improvement, mRS modified Rankin Scale, NRI net reclassification index, TBIL total bilirubin
  2. aAdjusted for age, sex, history of diabetes, atrial fibrillation/flutter, smoking status, stroke subtype, hypoglycemic agents, antiplatelet agents, baseline National Institutes of Health Stroke Scale score, total cholesterol, high density lipoprotein cholesterol, triglyceride, high sensitivity C-reactive protein, alanine aminotransferase and aspartate aminotransferase