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Table 3 The median survival time from onset of symptoms until the primary end point is calculated in association with ΔFS’ divided into two groups by the 50% quantile, ΔFS’ divided arbitrarily into three groups, and with age divided by the 50% quantile

From: Prediction of survival in amyotrophic lateral sclerosis: a nationwide, Danish cohort study

 

Kaplan-Meier survival analysis

Cox proportional hazards

No. of pts.

MST

p (log-rank)

Hazard Ratio

CI

p

ΔFS’

 Group 1, < 0.68 (Slow)

45

46.5

1

 Group 2, ≥0.68 (Fast)

45

25.2

1.3e-7

3.66

2.17–6.18

1.1e-6

ΔFS’

  < 0.5 (Slow)

29

55.5

1

 0.5–1.0 (Medium)

34

31.7

5.5e-5

3.12

1.66–5.85

3.9e-4

  > 1.0 (Fast)

27

19.8

0.0032

7.50

3.71–15.17

2.1e-8

Age (yrs)

  < 65.2

45

40.4

1

  ≥ 65.2

45

25.9

8.0e-4

2.18

1.34–3.54

0.0017

  1. CI Confidence interval, ΔFS’ ALSFRS-R progression rate, MST Median survival time (from onset of symptoms until primary endpoint in months), p: p-value, pts. Patients, yrs. Years