From: Prediction of survival in amyotrophic lateral sclerosis: a nationwide, Danish cohort study
(A) | (B) | ||||||
---|---|---|---|---|---|---|---|
Variable | HR | p | Variable | HR | p | HR coefficient | p |
Age at onset (yrs) | Age at onset (yrs) | ||||||
< 65.2 | 1 | – | < 65.2 | 1 | – | – | – |
≥65.2 | 2.18 (1.34–3.54) | 0.0017 | ≥65.2 | 2.56 (1.56–4.22) | 2.2e-4 | 1.07 (1.04–1.10) | 3.0e-6 |
Onset to diagnosis (mo) | Onset to diagnosis (mo) | ||||||
< 12.7 | 1 | – | < 12.7 | 1 | – | – | – |
≥12.7 | 0.45 (0.28–0.73) | 0.013 | ≥12.7 | 0.52 (0.31–0.86) | 0.01 | 0.52 (0.37–0.73) | 1.4e-4 |
ΔFS’ | ΔFS’ | ||||||
< 0.68 | 1 | – | < 0.68 | 1 | – | – | – |
≥0.68 | 3.66 (2.17–6.18) | 1.1e-6 | ≥0.68 | 3.3 (1.91–5.69) | 1.8e-5 | 2.19 (1.67–2.88) | 1.6e-8 |
ALSFRS-R at test date | |||||||
< 36.5 | 1 | – | |||||
≥36.5 | 0.97 (0.61–1.57) | 0.91 | |||||
Sex (n) | |||||||
Female (39) | 1 | – | |||||
Male (51) | 0.92 (0.57–1.48) | 0.74 | |||||
Onset site (n) | |||||||
Mixed (6) | 1 | – | |||||
Truncal (1) | 0.95 (0.11–8.2) | 0.96 | |||||
Bulbar (26) | 0.85 (0.32–2.28) | 0.75 | |||||
Spinal (57 | 0.78 (0.31–1.98) | 0.60 |