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Fig. 4 | BMC Neurology

Fig. 4

From: Low free triiodothyronineis predicts worsen neurological outcome of patients with acute ischemic stroke: a retrospective study with bioinformatics analysis

Fig. 4

Differences in gene expression profiles between neuron treated by T3 and sham groups. a. Standardization of GSE data. The blue bar represents the data before normalization, and the red bar represents the normalized data. Black lines in the boxes represent medians. b. Volcano plots show the distributions of gene expression between the treated and sham groups. The horizontal line corresponds to a 2-fold change up or down, and the vertical line represents a P-value< 0.05. The red points represent upregulated genes on the basis of |fold change| > 2.0 and P value < 0.05. The green points represent downregulated genes screened on the basis of |fold change| > 2.0 and a corrected P-value < 0.05. The black points represent genes with no significant difference. FC, fold change. c. Hierarchical clustering heatmap of DEGs screened on the basis of |fold change| > 2.0 and a corrected P-value < 0.05.The left vertical axis shows clusters of DEGs, and the above horizontal axis shows clusters of samples. Red represents up-regulated genes and green represents down-regulated genes, and black indicates no significant changes in gene expression; gray indicates that the signal strength of genes was not high enough to be detected. DEGs, differentially expressed genes

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