Fig. 3
From: PPAR-γ promotes p38 MAP kinase-mediated endothelial cell permeability through activating Sirt3
Expression of endothelial associated protein as induced in I/R model mRNA (a-d) and protein levels (e) of Sirt3, p38 as well as a few other permeability associate proteins in HBMEC at 24 h of reperfusion after I/R injury. Cells were either from normal HBMECs with SIRT3 inhibition (BLANK and 3-TYP), or from I/R injury HBMECs at 24 h of post-reperfusion with SIRT3 overexpression, together with or without U-46619 treatment (Control, Vector, Sirt3 and Sirt3 + U-46619). ***, p < 0.001 as compared to the normal HBMECs model (BLANK). ### or ##, p < 0.001 or p < 0.01 as compared to the non-overexpression control group (Control) and!!! as compared to the Sirt3 overexpression group (Sirt3)