BMC Neurology

Table 4 MDR models of gene-gene interactions between three SNPs

From: Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population

SNP	IS					LAA
SNP	Best candidate model	Training accuracy	Testing accuracy	CVC	Permutation test P value	Best candidate model	Training accuracy	Testing accuracy	CVC	Permutation test P value
1	SNP3	0.5216	0.4981	7 /10	0.206	SNP3	0.5342	0.5342	10/10	0.4270
2	SNP1 SNP3	0.5375	0.5211	10 /10	0.300	SNP1 SNP3	0.5504	0.5346	10/10	0.8400
3	SNP1 SNP2 SNP3	0.5445	0.5176	10 /10	0.330	SNP1 SNP2 SNP3	0.5591	0.5185	10/10	0.5600
SNP	CES					SVO
SNP	Best candidate model	Training accuracy	Testing accuracy	CVC	Permutation test P value	Best candidate model	Training accuracy	Testing accuracy	CVC	Permutation test P value
1	SNP1	0.5228	0.4834	5/10	0.7600–0.7610	SNP1	0.53	0.53	10 /10	0.8520
2	SNP1 SNP3	0.5383	0.4776	10/10	0.9510	SNP1 SNP3	0.5428	0.5304	10 /10	0.0050–0.0060
3	SNP1 SNP2 SNP3	0.5552	0.4592	10/10	0.7990–0.8000	SNP1 SNP2 SNP3	0.5496	0.5125	10 /10	0.0190–0.0200

P < 0.05 in bold
COX-1 rs1330344, rs3842788, COX-2 rs689466 signed as SNP1–3
CVC(cross-validation consistency)

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