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Table 2 Genotype and allele frequency distributions of SNPs in IS and controls

From: Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population

 

Control group (%)

IS group

LAA group

CES group

SVO group

n(%)

P value

OR(95%CI)

P value

OR(95%CI)

P value

OR(95% CI)

P value

OR(95% CI)

rs5788

 Genotype

  CC

810 (89.7)

974 (90.4)

–

Reference

–

Reference

–

Reference

–

Reference

  CA

89 (9.9)

102 (9.5)

0.384

2.634 (0.297–23.332)

0.657

0.894 (0.545–1.466)

0.465

1.254(0.684–2.298)

0.433

0.824 (0.507–1.338)

  AA

4 (0.4)

2 (0.2)

0.426

2.450 (0.270–22.255)

0.818

0.742 (0.058–9.471)

NA

–

0.539

0.380 (0.017–8.288)

  CA + AA vs CC

  

0.600

0.907 (0.629–1.307)

0.634

0.888 (0.546–1.446)

0.525

1.216 (0.665–2.224)

0.383

0.808 (0.500–1.305)

  AA vs CC + CA

  

0.388

0.382 (0.043–3.387)

0.825

0.750 (0.059–9.572)

NA

–

0.546

0.386 (0.018–8.454)

 Allele

  C

1709 (94.6)

2050 (95.1)

–

Reference

–

Reference

–

Reference

–

Reference

  A

97 (5.4)

106 (4.9)

0.498

0.884 (0.618–1.263)

0.510

0.851 (0.528–1.374)

0.586

1.173 (0.660–2.085)

0.413

0.824 (0.519–1.309)

rs1330344

 Genotype

  GG

126 (14.0)

177 (16.4)

–

Reference

–

Reference

–

Reference

–

Reference

  GA

456 (50.5)

510 (47.3)

0.350

0.827 (0.555–1.232)

0.426

0.815 (0.402–1.350)

0.503

0.809 (0.436–1.503)

0.207

0.739 (0.463–1.182)

  AA

321 (35.5)

391 (36.3)

0.044

0.657 (0.437–0.988)

0.108

0.652 (0.387–1.099)

0.043

0.506 (0.262–0.978)

0.048

0.616 (0.382–0.995)

  GA + AA vs GG

  

0.133

0.794 (0.587–1.073)

0.239

0.781 (0.517–1.179)

0.178

0.699 (0.415–1.177)

0.050

0.690 (0.475–1.000)

  AA vs GG + GA

  

0.588

0.939 (0.748–1.179)

0.623

0.927 (0.685–1.254)

0.132

0.723 (0.474–1.102)

0.698

0.944 (0.708–1.260)

 Allele

  G

708 (39.2)

864 (40.1)

–

Reference

–

Reference

–

Reference

–

Reference

  A

1098 (60.8)

1292 (59.9)

0.029

0.812 (0.675–0.978)

0.034

0.778 (0.618–0.981)

0.023

0.702 (0.518–0.951)

0.097

0.829(0.665–1.035)

rs3842788

 Genotype

  GG

795 (88.0)

890 (82.6)

–

Reference

–

Reference

–

Reference

–

Reference

  GA

97 (10.7)

120 (11.1)

0.337

0.821 (0.549–1.228)

0.122

0.652 (0.379–1.122)

0.861

0.944 (0.495–1.801)

0.591

0.876 (0.540–1.420)

  AA

11 (1.3)

68 (6.3)

0.165

5.127 (0.511–5.428)

0.128

7.858 (0.552–111.969)

0.082

9.758 (0.748–12.273)

0.326

4.586 (0.219–5.902)

  GA + AA vs GG

  

0.487

0.868 (0.583–1.293)

0.206

0.711 (0.419–1.207)

0.882

1.048 (0.562–1.955)

0.692

0.908 (0.563–1.465)

  AA vs GG + GA

  

0.016

5.203 (1.519–5.159)

0.121

8.167 (0.573–16.414)

0.041

9.821 (2.754–12.832)

0.025

4.603 (1.220–5.201)

 Allele

  G

1687 (93.4)

1900 (88.1)

–

Reference

–

Reference

–

Reference

–

Reference

  A

119 (6.6)

256 (11.9)

0.699

0.928 (0.635–1.355)

0.354

0.789 (0.479–1.302)

0.620

1.157 (0.650–2.057)

0.817

0.947 (0.600–1.496)

rs20417

 Genotype

  GG

812 (89.9)

977 (90.6)

–

Reference

–

Reference

–

Reference

–

Reference

  GC

87 (9.6)

97 (9.0)

0.680

1.080 (0.748–1.561)

0.424

1.223 (0.746–2.006)

0.812

1.084 (0.556–2.114)

0.423

1.211 (0.758–1.935)

  CC

4 (0.4)

4 (0.4)

0.341

421 (0.071–2.500)

0.528

0.443 (0.035–5.560)

0.479

0.335 (0.016–6.937)

0.528

0.499 (0.058–4.315)

  GC + CC vs GG

  

0.820

1.043 (0.726–1.498)

0.513

1.177 (0.723–1.915)

0.953

1.020 (0.528–1.970)

0.513

1.166 (0.736–1.848)

  CC vs GG + GC

  

0.378

0.418 (0.070–2.482)

0.519

0.436 (0.035–5.460)

0.477

0.334 (0.016–6.899)

0.518

0.492 (0.057–4.239)

 Allele

  G

1711 (94.7)

2051 (95.1)

–

Reference

–

Reference

–

Reference

–

Reference

  C

95 (5.3)

105 (4.9)

0.952

0.987 (0.655–1.489)

0.630

1.137 (0.675–1.914)

0.963

0.984 (0.504–1.924)

0.646

1.124 (0.684–1.847)

rs689466

 Genotype

  GG

189 (20.9)

241 (22.4)

–

Reference

–

Reference

–

Reference

–

Reference

  GA

472 (52.3)

519 (48.1)

0.408

0.888 (0.671–1.176)

0.435

0.861 (0.592–1.253)

0.676

1.116 (0.666–1.872)

0.230

0.805 0.565–1.147)

  AA

242 (26.8)

318 (29.5)

0.535

1.104 (0.807–1.511)

0.262

1.266 (0.838–1.910)

0.871

1.050 (0.581–1.897)

0.883

1.030 (0.692–1.533)

  GA + AA vs GG

  

0.758

0.959 (0.735–1.251)

0.960

0.991 (0.697–1.409)

0.791

1.095 (0.667–1.797)

0.438

0.876 (0.627–1.224)

  AA vs GG + GA

  

0.140

1.201 (0.941–1.531)

0.038

1.404 (1.019–1.934)

0.890

0.969 (0.617–1.520)

0.251

1.200 (0.879–1.638)

 Allele

  G

850 (47.1)

1001 (46.4)

–

Reference

–

Reference

–

Reference

–

Reference

  A

956 (52.9)

1155 (53.6)

0.969

0.996 (0.829–1.198)

0.541

1.076 (0.851–1.360)

0.799

0.962 (0.712–1.300)

0.678

0.954 (0.764–1.192)

  1. Using multivariate analysis after adjusting for age, gender and traditional risk factors
  2. P < 0.05 in bold
  3. NA Not available
  4. Reference: means allele homozygote as a reference
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