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Table 1 Titers and lab values

From: Demyelinating syndrome in systemic sclerosis and neuromyelitis optica

Test name

Titers

Reference ranges

 

Neuromyelitis Optica... 7.7 A

Negative 0.0–3.0;Indeterminate 3.1–5.0;Positive > 5.1

ANA Positive

 

ANTI-DNA < 1.0

Negative: <=4.9 IU/mL;Indeterminate: 5–9.9 IU/mL;Positive: > = 10 IU/mL

Smooth Muscles

SM AB < 0.2

Negative: < 1.0;Positive: > = 1.0

Neutrophil Cytoplasmic Ab

C-ANCA < 0.2, P-ANCA < 0.2

Negative: < 1.0;Positive: > = 1.0

Scleroderma 70 Ab

SCLERODERM... 4.5 H

Negative: < 1.0;Positive: > = 1.0

JO-1 ANTIB... <  0.2

Negative: < 1.0;Positive: > = 1.0

CENTROMERE AB... <  0.2

Negative: < 1.0;Positive: > = 1.0

Sjorgen

ANTI-SSA... <  0.2, ANTI-SSB... <  0.2

Negative: < 1.0;Positive: > = 1.0

RNP AB < 0.2

Negative: < 1.0;Positive: > = 1.0

CHROMATIN ... <  0.2

Negative: < 1.0;Positive: > = 1.0

RA Negative

 

HBsAg Scre... NEGATIVE

 

HEP B SURF... NEGATIVE

 

RNA Polymerase III IgG Abs 40 Units/mL

Negative: < 20;Weak Positive: 20–39;Moderate Positive: > 40–80;Strong Positive: > 80a

C3 131

 

C4 40

 

HIV By By RT-PCR

HIV RNA... Target Not Detected

 

Toxoplasma Igg

TOXOPLASMA... 27.0 H,

 

TOXOPLASMA... 0.24

<  0.9 Negative;0.9–0.99 Equivocal;>  1.00 Positive

MYELIN BASIC PROTEIN... 6.3 A

 

EBV EARLY ... <  0.20, EBV NUCLEA... >  8.00 H,

 

EBV VCA IG... >  8.0 H, EBV VCA IG... <  0.2

< OR = 0.8 AI: NEGATIVE;0.9–1.0 AI: EQUIVOCAL;> OR = 1.1 AI: POSITIVE

VARICELLA IgG … .3.3

< OR = 0.8 AI: NEGATIVE;0.9–1.0 AI: EQUIVOCAL;> OR = 1.1 AI: POSITIVE

HTLV I/II ... TNP

 

Epst Barr Virus DNA

Epst Barr ... Negative

 

Varicella Zoster Ab Pcr (Csf)

VARICELLA ... Negative

 

Crypto.Ag,Csf

CRYPTO.AG,... Negative

 

Herpes Virus Dna By Pcr

HSV1 DNA P... Negative, HSV2 DNA P... Negative

 

Lyme Disease Ab (Csf)

B.burgd Ig... < 0.08, B.burgd Ig... < 0.06

Negative: < or = 0.09;Positive: >  0.09B.

Enterovirus... Negative

 

CSF VDRL Nonreactive

 

IGG 1500

 

Coccidioides Abs, CSF (CF) < 1:2 < 1:2

 

Coccidioides Ab, IgG 0.1 IV < =0.9

 

Toxo IgG C... < 3.0

 

Oligoclonal

OLIGOCLONAL ab negative

 

GLUCOSE, C... 99 H; PROT.,CSF 55.6 H

 

Immunofix/Pep Csf Profile

PROTEIN (C... 36.9, PREALBUMIN 2.9,

 

ALBUMIN 54.5 A, ALPHA-1-GL... 4.1, ALPHA-2-GL... 6.4,

 

BETA GLOBU... 17.8, GAMMA GLOB... 14.4 A

 

Lymph/Leuk Body Fluid

plasma cells are not identified

T cells with an increased CD4/CD8 ratio are detected. b

ANGIOTENSIN ENZYM < 15

 

Renin Activity... 13.774 A

 

D-DIMER 476 H

 

CORTISOL 34.66

 

TSH 0.910

 

ESR 86 H

 

CRP-HIGH S... 1.910 H

 
  1. aRNA Polymerase III is strongly associated with diffuse cutaneous scleroderma and with an increases risk of acute renal crisis. A positive result supports a possible diagnosis of systemic sclerosis while a negative result does not rule out the possibility of systemic sclerosis, as the sensitivity for detection of RNA Polymerase III is between 11 and 23%
  2. bFlow cytometric analysis identifies a population of lymphocytes (91.1% of all analyzed events) that consists of a mixture of minute B-cell population (2.7% of cells in this gate), T cells with an increased CD4/CD8 ratio of 7.8 and mild down-regulation of CD7 expression (91.6% of cells in this gate), and NK-cells (2.0% of cells in this gate). An increased CD4/CD8 ratio is a non-specific finding that may be seen in reactive / inflammatory processes and autoimmune disease; less likely, it may represent an atypical population. The B-cells show minimal lambda excess, the significance of which is uncertain
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BMC Neurology

ISSN: 1471-2377

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