Fig. 1
From: Increase of CSF inflammatory profile in a case of highly active multiple sclerosis
(A) Patient’s history was characterized by sustained disease activity. Red arrows correspond to relapses, which caused disability accumulation. Red pentagons correspond to disease activity at MRI follow up characterized by new T2 lesions or T1 Gd-enhancing lesions. Lumbar puncture was performed in 2006 and 2013. GA Glatiramer acetate; IFNB1a Interferon Beta-1a; NTZ Natalizumab; PEX Plasma Exchange; CFX cyclophosphamide; DMF Dimethyl-fumarate; ALM Alemtuzumab. (B) Brain 3 T-MRI obtained at the time of second lumbar puncture (a, d, f) and during a subsequent follow up of 2015 (b, c, e, g). Axial 3D Fluid Attenuated Inversion Recovery (FLAIR, a, b), post contrast T1w (c), 3D Double Inversion Recovery (d, e), spinal cord STIR (f, g) are shown. Arrows indicate new lesions