Table 1 Baseline variables of switchers and naïve patients and statistical comparison using the χ2 or the MW test
Variables | Switchers (n = 64) | Naïve (n = 130) | p |
|---|---|---|---|
Age [years (IQR)] | 41.5 (33.0–48.2) | 36.0 (29.0–45.0) | 0.014 |
Sex | |||
M [n (%)] | 10 (15.6) | 28 (21.5) | 0.496 |
F [n (%)] | 47 (73.4) | 92 (70.8) | |
NA [n (%)] | 7 (10.9) | 10 (7.7) | |
Disease course | |||
CIS [n (%)] | 4 (6.2) | 32 (24.6) | 0.003 |
RRMS [n (%)] | 60 (93.8) | 98 (75.4) | |
Last treatment | |||
INF [n (%)] | 38 (59.4) | NA | |
FTY [n (%)] | 5 (7.8) | NA | |
DMF [n (%)] | 3 (4.7) | NA | |
NTZ [n (%)] | 11 (17.2) | NA | |
MTX [n (%)] | 1 (1.6) | NA | |
NA [n (%)] | 6 (9.4) | NA | |
Age at disease onset [years (IQR)] | 31.0 (24.0–39.5) | 31.0 (26.0–40.0) | 0.662 |
Disease duration [years (IQR)] | 6.0 (3.0–13.0) | 1.0 (0.0–5.0) | 1.50E-08 |
ARR previous 24 months | 0.5 (0.0–0.5) | 0.5 (0.5–1.0) | 0.005 |
EDSS at V1 [score (IQR)] | 2.5 (2.0–3.8) | 2.0 (1.5–2.5) | 0.0006 |
V1 - GA treatment [days] (IQR)] | 0.5 (−2.2–16.7) | 3.0 (− 7.0–16.0) | 0.961 |