Table 2 Skin reactions reported under therapy with peginterferon beta-1a, interferon beta 1a and 1b, respectively
Frequency according to SmPC of respective drug | SC peginterferon beta-1a [19] | IM interferon beta-1a [21] | SC interferon beta-1a [22] | SC interferon eta 1b [23] |
|---|---|---|---|---|
Very common ≥1/10 | IS erythema, IS pain, IS pruritus | IS inflammation, IS skin disorder reaction | IS reaction (different kinds), sweating | |
Common ≥1/100, < 1/10 | IS oedema, IS warmth, IS haematoma, IS rash, IS swelling, IS discolouration, IS inflammation | Rash, increased sweating, contusion, IS pain, IS erythema, IS bruising | Pruritus, rash, erythematous rash, maculo-papular rash, alopecia, IS pain | Erythema, swelling, inflammation, pain, abscess, skin disorder, rash, urticaria, pruritus, alopecia, IS necrosis |
Uncommon ≥1/1.000, < 1/100 | Urticaria, hypersensitivity reaction | Alopecia, IS burning | Urticaria, IS necrosis, IS swelling, IS infections*, increased sweating | Skin discolouration |
Rare ≥1/10.000, < 1/1.000 | IS necrosis | Quincke’s oedema (angio-oedema), erythema multiforme, erythema, multiforme-like skin reactions, Stevens Johnson syndrome, IS cellulitis, anaphylactic reactions | ||
Unknown | Angioneurotic oedema, pruritus, rash vesicular, urticaria, IS reaction, IS inflammation, IS cellulitis, IS necrosis, IS bleeding, anaphylactic reactions, hypersensitivity reaction (angio-oedema, dyspnea, urticarial, rash, pruritus) | Drug induced lupus erythematodes |